HU Pei-pei,GAO Yu,ZHAO Jiu-ru,et al.Birth outcomes in pregnant women with assisted reproductive technology exposure to organophosphate pesticides in Shanghai[J].同济大学学报（医学版）,2020,41(5):567-574. [点击复制]
Birth outcomes in pregnant women with assisted reproductive technology exposure to organophosphate pesticides in Shanghai
HU Pei-pei,GAO Yu,ZHAO Jiu-ru,LI Hong,LIU Zhi-wei,DING Guo-dong
(Dept. of Pediatrics, East Hospital, Tongji University School of Medicine, Shanghai 200012, China;Dept. of Environmental Health, Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China;Dept. of Neonatology, International Peace Maternity and Child Health Hospital of China Welfare Institution, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China;Dept. of Neonatology, International Peace Maternity and Child Health Hospital of China Welfare Institution, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Dept. of Nursing, International Peace Maternity and Child Health Hospital of China Welfare Institution, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China;Dept. of Pediatrics, East Hospital, Tongji University School of Medicine, Shanghai 200012, China; Dept. of Respiratory Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University, Shanghai 200040, China)
Abstract:
ObjectiveTo investigate the association between birth outcomes and exposure levels of organophosphate pesticides(OPs) in pregnant women undergoing assisted reproduction techniques(ART). MethodsThe participants were recruited from the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, between July 2017 and December 2018. From 597 women who met the eligibility criteria, 106 singleton live born mother-neonate pairs were included in this study. Preconception exposure to OPs was assessed by measuring six non-specific dialkylphosphate(DAP) metabolites in urine[dimethylphosphate(DMP), dimethyldithiophosphate(DMTP), dimethyldithiophosphate(DMDTP), diethylphosphate(DEP), diethylthiophosphate(DETP) and diethyldithiophosphate(DEDTP)]. Generalized linear models(GLMs) were used to explore the relationship between OP exposures and birth outcomes. ResultsThe detection frequencies of DAP metabolites were high for DEP(91.5%), DETP(95.3%), DMP(91.5%) and DMTP(87.7%), were low for DMDTP(12.1%) and DEDTP(2.0%). We found that DETP metabolite levels were negatively associated with gestational age(β=-1.34,95%CI：-2.24~-0.45). When stratified by neonatal gender, we found the similar results among male neonates(β=-1.72,95%CI：-3.02~-0.43), but not among female neonates. ConclusionThe OP exposure levels in Shanghai were much higher than those reported in developed countries, and the adverse effects of OPs on gestational age were more pronounced among male than female neonates.
