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  • 王小梅,廖丽君,王清秀.纤维肌痛症发病机制的研究进展[J].同济大学学报(医学版),2020,41(4):518-522.    [点击复制]
  • WANG Xiao-mei,LIAO Li-jun,WANG Qing-xiu.Research progress the pathogenesis of fibromyalgia[J].同济大学学报(医学版),2020,41(4):518-522.   [点击复制]
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纤维肌痛症发病机制的研究进展
王小梅,廖丽君,王清秀
0
(南京医科大学上海东方临床医学院,南京 210029;同济大学附属东方医院麻醉科/疼痛科,上海 200120)
摘要:
纤维肌痛症(fibromyalgia, FM)是一种骨骼肌肉广泛持续性疼痛为主要特征的慢性进展性疾病,临床上往往伴随焦虑、抑郁、睡眠障碍、慢性疲乏或胃肠道功能紊乱等症状。其发病机制仍不明,目前尚无确切疗法,严重影响患者生活质量。近年来研究发现FM与氧化应激、中枢疼痛敏化、转运体蛋白遗传多态性、生物胺含量及功能异常、炎症因子过度释放、肠道菌群紊乱或维生素D缺乏等相关。本文就FM发病机制进行综述,为进一步研究提供参考。
关键词:  纤维肌痛症  氧化应激  生物胺  肠道菌群  中枢敏化  转运体蛋白
DOI:10.16118/j.1008-0392.2020.04.021
投稿时间:2019-12-18
基金项目:国家自然科学基金面上项目(8197081239);江西省自然科学基金面上项目 (20192BAB2050)
Research progress the pathogenesis of fibromyalgia
WANG Xiao-mei,LIAO Li-jun,WANG Qing-xiu
(Shanghai East Hospital Clinical Medical College, Nanjing Medical University, Nanjing 210029, China;Dept. ofAnesthesiology and Pain management, East Hospital, Tongji University School of Medicine, Shanghai 200120, China)
Abstract:
Fibromyalgia (FM) is a syndrome characterized by widely and persistent pain in skeletal muscles, often accompanied by symptoms of anxiety, depression, sleep disturbance, chronic fatigue or gastrointestinal disorder symptoms. Its pathogenesis is still unknown and there is no effective treatment so far, which seriously affects the quality of life of patients. Recent studies have found that fibromyalgia is associated with oxidative stress, central pain sensitization, translocator protein polymorphism, abnormal biogenic amine output and function, excessive release of inflammatory factors, gut microbiota disorders or vitamin D deficiency. This review summarized the pathogenesis of fibromyalgia to provides some clues for further research.
Key words:  fibromyalgia  oxidative stress  biogenic amines  gut microbiota  central sensitization  translocator protein

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