引用本文
  • 周雅洁,李新明.CDK4/6抑制剂帕博西尼的研究进展[J].同济大学学报(医学版),2020,41(2):259-263.    [点击复制]
  • ZHOU Ya-jie,LI Xin-ming.Advances of CDK4/6 inhibitor palbociclib in cancer treatment[J].同济大学学报(医学版),2020,41(2):259-263.   [点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 51次   下载 29 本文二维码信息
码上扫一扫!
CDK4/6抑制剂帕博西尼的研究进展
周雅洁,李新明
0
(贵州医科大学临床医学院,贵阳550004;上海健康医学院附属周浦医院,上海200120)
摘要:
细胞周期蛋白依赖性激酶(cyclin-dependent kinases, CDKs)在细胞周期的调控中起着至关重要的作用,是干扰肿瘤细胞分裂和增殖的特异治疗靶点。帕博西尼是全球首个CDK4/6特异性抑制剂,临床疗效显著,毒性可控,被批准联合来曲唑治疗绝经后ER+、HER2-的晚期乳腺癌患者,作为转移性疾病的初始内分泌治疗。目前已经开始研究这种抑制剂对其他恶性肿瘤的疗效。本文综述了帕博西尼的作用机制及其在不同肿瘤治疗中的研究进展,并对帕博西尼的发展前景进行了展望。
关键词:  帕博西尼  细胞周期蛋白依赖性激酶4/6  肿瘤  心脏毒性
DOI:10.16118/j.1008-0392.2020.02.021
投稿时间:2019-03-27
基金项目:上海浦东新区卫健委重点学科群项目(PWZxq2017-01);上海健康医学院协同创新项目(SPCI-17-17-001)
Advances of CDK4/6 inhibitor palbociclib in cancer treatment
ZHOU Ya-jie,LI Xin-ming
(Clinical Medical College, Guizhou Medical University, Guiyang 550004, China;Zhoupu Hospital Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201318, Chi)
Abstract:
Cyclin-dependent kinases(CDKs) play a pivotal role in cell cycle regulation, which makes them a distinct therapeutic target to interfere with cell division and proliferation in cancer patients. Palbociclib is the first and specific inhibitor of CDK4/6 with excellent clinical efficacy and limited toxicity. It has been approved in combination with letrozole for the treatment of postmenopausal women with ER+ and HER2- advanced metastatic breast cancer as initial endocrine-based therapy. Extensive studies have also shown that this inhibitor may be used as a potential targeting drug for treatment of other cancers. This review describes the action and mechanism of palbociclib in breast cancer treatment and preclinical studies in other cancers, as well as prospects in the development of palbociclib.
Key words:  palbociclib  CDK4/6  neoplasm  cardiotoxicity

您是第2025681位访问者
版权所有《同济大学学报(医学版)》编辑部
主管单位:教育部 主办单位:同济大学
地  址: 上海四平路1239号 邮编:200092 电话:021-65980705 E-mail: yxxb@tongji.edu.cn
本系统由北京勤云科技发展有限公司设计