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  • 刘鹏飞,马文静,赵爱华,等.RNA干扰技术防治新型冠状病毒肺炎的思考和展望[J].同济大学学报(医学版),2020,41(2):141-146.    [点击复制]
  • LIU Peng-fei,MA Wen-jing,ZHAO Ai-hua,et al.Prospect on the application of RNA interference technique to prevent and treat coronavirus disease 2019[J].同济大学学报(医学版),2020,41(2):141-146.   [点击复制]
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RNA干扰技术防治新型冠状病毒肺炎的思考和展望
刘鹏飞,马文静,赵爱华,谭天浩,赵倩,俞作仁
0
(同济大学医学院东方医院转化医学研究中心,上海200120;甘肃省武威市中医医院,甘肃 武威733000)
摘要:
新型冠状病毒肺炎(coronavirus disease 2019, COVID-19)对社会和人类健康造成严重了的危害。除了要严格控制病毒传播外,当务之急是探索新的治疗策略,开发新的治疗药物,努力提高患者生存率和生存质量。本文回顾了当前抗病毒药物研发的途径,并结合此次新型冠状病毒(SARS-CoV-2)基因组特点和RNA干扰(RNA interference, RNAi)技术在相关领域中的研究进展,分析了将RNAi技术应用于COVID-19防治的可行性、优势与需要克服的问题。
关键词:  新型冠状病毒  RNA干扰  新药研发  综述
DOI:10.16118/j.1008-0392.2020.02.001
投稿时间:2020-02-26
基金项目:科技部重点研发计划(2020YFC0842200);同济大学“中央高校基本科研业务费专项资金”(22120200002)
Prospect on the application of RNA interference technique to prevent and treat coronavirus disease 2019
LIU Peng-fei,MA Wen-jing,ZHAO Ai-hua,TAN Tian-hao,ZHAO Qian,YU Zuo-ren
(Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China;The Traditional Chinese Medicine Hospital of Wuwei, Wuwei 733000, Gansu Province, China)
Abstract:
Coronavirus disease 2019(COVID-19) has caused serious health threat in the society. In addition to minimize the spread of the virus, it is in urgent need to explore new treatment strategies, develop new treatment drugs to improve patient survival and quality of life. This article reviews current approaches to develop antiviral drugs. In addition, based on the genomic characteristics of the novel coronavirus and the research advances of RNA interference(RNAi) technique in the related fields, we analyze the feasibility, advantages and problems to overcome of RNA interference technique in prevention of COVID-19 infection and treatment of the patients.
Key words:  coronavirus disease 2019  RNA interference  new drug development  review

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