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  • 吕梦伟,章 兴,张杨杨.环状RNA在心血管疾病临床诊断和预警中的研究进展[J].同济大学学报(医学版),2020,41(1):130-135.    [点击复制]
  • LV Meng-wei,ZHANG Xing,ZHANG Yang-yang.Research advances of circRNA in diagnosis and prediction of cardiovascular diseases[J].同济大学学报(医学版),2020,41(1):130-135.   [点击复制]
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环状RNA在心血管疾病临床诊断和预警中的研究进展
吕梦伟,章兴,张杨杨
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(南京医科大学上海东方临床医学院,南京 210029;同济大学心律失常教育部重点实验室,上海 200120;南京医科大学儿科学院,南京 211166; 同济大学附属东方医院心脏大血管外科,上海 200120)
摘要:
环状RNA(circular RNA, circRNA)是一类双链闭合非编码RNA,在心血管疾病发生发展中起着重要的调节作用,它具有相对稳定、特异表达、进化保守等生物学特性,是目前研究的热点之一,在心血管疾病诊断和预警方面具有潜在的应用前景。本文介绍circRNA在多种常见心血管疾病临床诊断和预警的应用现状。
关键词:  环状RNA  心血管疾病  诊断  预测  临床价值
DOI:10.16118/j.1008-0392.2020.01.023
投稿时间:2019-04-21
基金项目:科技部国家重点研发计划项目(2018-YFC-1312505);江苏省“六大人才高峰”项目(2015-WSW-019);江苏省高等学校大学生创新创业训练计划(201810312058X)
Research advances of circRNA in diagnosis and prediction of cardiovascular diseases
LV Meng-wei,ZHANG Xing,ZHANG Yang-yang
(Shanghai East Clinical Medical College, Nangjing Medical University, Nanjing 210029, China; Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine, Shanghai 200120, China;School of Pediatrics, Nanjing Medical University, Nanjing 211166, China;Shanghai East Clinical Medical College, Nangjing Medical University, Nanjing 210029, China; Key Laboratory of Arrhythmias of the Ministry of Education of China, Tongji University School of Medicine, Shanghai 200120, China; Dept. of Cardiovascular Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120, China)
Abstract:
Circular RNA(circRNA), a kind of double-stranded closed non-coding RNA, plays essential roles in the development and progression of cardiovascular diseases. CircRNA is relatively stable with the characteristics of specific expressions and evolutionary conservation. Circ RNA has potential value in the diagnosis and early prediction of cardiovascular diseases and becomes one of the hotspots of current researches. This article reviews the current application of circRNA in clinical diagnosis and early prediction of cardiovascular diseases.
Key words:  circular RNA  cardiovascular diseases  diagnosis  forecasting  clinical value

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