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  • 邵启蕙,郭颂铭,董秋安.自拟“溃结2号方”治疗溃疡性结肠炎的临床观察[J].同济大学学报(医学版),2020,41(1):112-116.    [点击复制]
  • SHAO Qi-hui,GUO Song-ming,DONG Qiu-an.Efficacy of Kuijie No.2 prescription for patients with ulcerative colitis[J].同济大学学报(医学版),2020,41(1):112-116.   [点击复制]
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自拟“溃结2号方”治疗溃疡性结肠炎的临床观察
邵启蕙,郭颂铭,董秋安
0
(同济大学附属同济医院中医科,上海 200065)
摘要:
目的 观察“溃结2号方”对溃疡性结肠炎临床疗效及对细胞因子含量的影响。方法 将来自同济大学附属同济医院及上海中医药大学附属岳阳中西医结合医院的98例溃疡性结肠炎患者随机分成中药治疗组和西药对照组(每组49例),中药组给予“溃结2号方”治疗,西药对照组给予美沙拉秦治疗,疗程为8周。对比观察两组溃疡性结肠炎患者治疗前后的症状,并观察临床有效率、复发率,内毒素及其炎症因子IL-4、TNF-α、IL-8、IL-23含量变化。结果 中药组治疗后症状分级量化积分显著低于对照组(P<0.05);临床治疗总有效率(89.79%)高于对照组,但差异无统计学意义(P>0.05);中药组复发率(10.20%)低于对照组(P<0.05);治疗后两组IL-4含量升高,内毒素及炎症因子TNF-α、IL-8、IL-23含量降低,但中药组IL-4含量明显高于对照组(P<0.05),中药组内毒素、TNF-α、IL-8、IL-23的含量明显低于对照组(P<0.05)。结论 “溃结2号方”治疗溃疡性结肠炎,有助于改善其中医病症,有效降低了溃疡性结肠炎的复发率,改善异常的内毒素及炎症因子IL-4、TNF-α、IL-8、IL-23含量,从而提高溃疡性结肠炎的临床疗效。
关键词:  溃结2号方  溃疡性结肠炎  临床观察  疗效
DOI:10.16118/j.1008-0392.2020.01.020
投稿时间:2019-09-12
基金项目:上海市科学技术委员会项目(16401971400)
Efficacy of Kuijie No.2 prescription for patients with ulcerative colitis
SHAO Qi-hui,GUO Song-ming,DONG Qiu-an
(Dept. of Traditional Chinese Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China)
Abstract:
Objective To assess the efficacy of Kuijie No.2 for patients with ulcerative colitis. Methods Ninety eight patients with ulcerative colitis treated in Tongji hospital and YueYang Hospital were randomly assigned to receive traditional Chinese medicine Kuijie No.2(TCM group, n=49) or Western medicine(control group, n=49) for 8 weeks. The symptom scores, clinical effective rate, recurrence rate were determined; and the endotoxin and inflammatory factors IL-4, TNF-α, IL-8, IL-23 levels were measured before and after treatment. Results After treatment, the score of symptom classification in TCM group was significantly lower than that in the control group(P<0.05). There was a increasing trend of total effective rate in clinical treatment(89.79%), but there was no significant difference compared with control group(P>0.05). The recurrence rate in TCM group(10.20%) was significantly lower than that in the control group(P<0.05). After treatment, serum level of IL-4 was increased, the levels of endotoxin, TNF-α, IL-8 and IL-23 were decreased in both groups; while the IL-4 level in TCM group was significantly higher than that in control group(P<0.05), the endotoxin, TNF-α, IL-8 and IL-2 levels in the TCM group were significantly lower than those in the control group(P<0.05). Conclusion Treatment with TCM Kuijie No.2 can improve patients’ symptoms, reduce the disease recurrence rate, and change the abnormal endotoxin and inflammatory factors levels in patients with ulcerative colitis.
Key words:  Kuijie No.2  ulcerative colitis  clinical observation  efficacy

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