| 引用本文： |
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葛海燕,张振宇,茅丽玲,等.胃癌患者围手术期循环肿瘤细胞变化及其与临床病理分期的相关性[J].同济大学学报（医学版）,2020,41(1):47-50. [点击复制]
- GE Hai-yan,ZHANG Zhen-yu,MAO Li-ling,et al.Correlation of perioperative circulating tumor cells with clinicopathologic features of gastric cancer patients[J].同济大学学报（医学版）,2020,41(1):47-50. [点击复制]
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| 摘要: |
| 目的 了解胃癌患者围手术期外周血中循环肿瘤细胞(circulating tumor cells, CTCs)数量的变化及其与肿瘤病理分期的相关性。方法 应用肿瘤细胞微流控芯片技术检测手术前1天、手术后1周胃癌患者CTCs，并与其临床病理资料进行对比，阐明两者之间的相关性。结果 在92例胃癌患者中，术前外周血CTCs阳性者58例，阳性率为63%；CTCs阳性的胃癌患者与肿瘤浸润深度、脉管侵犯、神经侵犯都具有相关性（P=0.02）；术后1周60.5%患者CTCs消失或减少，CTCs数量没有变化甚至增多者主要见于TNM分期晚（Ⅳ期）患者。结论 胃癌患者外周血中CTCs与其临床病理分期具有密切相关性。 |
| 关键词: 胃癌 循环肿瘤细胞 肿瘤病理分期 胃癌根治术 临床研究 |
| DOI：10.16118/j.1008-0392.2020.01.008 |
| 投稿时间：2019-08-07 |
| 基金项目:上海市科学技术委员会项目（16411970800）；浙江省嘉兴市科技局课题项目（2015AY23071） |
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| Correlation of perioperative circulating tumor cells with clinicopathologic features of gastric cancer patients |
| GE Hai-yan,ZHANG Zhen-yu,MAO Li-ling,JI Fang,ZHU Zhe,GAO Wei,FU Zheng-wei |
| (Dept. of Gastrointestinal Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Second People’s Hospital, Pinghu 314200, Zhejiang Province, China;Nanxiang Community Health Service Center, Jiading District, Shanghai 201802, China) |
| Abstract: |
| Objective To investigate the correlation of perioperative circulating tumor cells(CTCs) with clinicopathologic features in gastric cancer patients. Methods The circulating tumor cells were detected with micro-fluid chip technique in 92 gastric cancer patients at 1 day before operation and 1 week after operation. The relationship between the CTCs and tumor clinicopathologic features of patients was analyzed. Results The positive CTCs were detected in 58 cases(63%) 1 day before operation. The positive CTCs were significantly correlated with cancer infiltration depth, blood vessel infiltration, and nerve infiltration（P=0.02）. The CTCs was negative or decreased in 60.5% of patients after 1 week of operation. The CTCs were increased or not changed mainly in TNM stage Ⅳ patients. Conclusion The positive CTCs in gastric cancer patients are closely correlated with clinicopathologic features. |
| Key words: gastric cancer circulating tumor cells tumor pathologic stages radical resections for gastric cancer clinical research |
