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  • 葛海燕,张振宇,茅丽玲,等.胃癌患者围手术期循环肿瘤细胞变化及其与临床病理分期的相关性[J].同济大学学报(医学版),2020,41(1):47-50.    [点击复制]
  • GE Hai-yan,ZHANG Zhen-yu,MAO Li-ling,et al.Correlation of perioperative circulating tumor cells with clinicopathologic features of gastric cancer patients[J].同济大学学报(医学版),2020,41(1):47-50.   [点击复制]
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胃癌患者围手术期循环肿瘤细胞变化及其与临床病理分期的相关性
葛海燕,张振宇,茅丽玲,纪昉,朱哲,高玮,付正伟
0
(同济大学附属东方医院胃肠肛肠外科,上海 200120; 浙江省平湖市第二人民医院,浙江 平湖 314200;上海市嘉定区南翔镇社区卫生服务中心,上海 201802)
摘要:
目的 了解胃癌患者围手术期外周血中循环肿瘤细胞(circulating tumor cells, CTCs)数量的变化及其与肿瘤病理分期的相关性。方法 应用肿瘤细胞微流控芯片技术检测手术前1天、手术后1周胃癌患者CTCs,并与其临床病理资料进行对比,阐明两者之间的相关性。结果 在92例胃癌患者中,术前外周血CTCs阳性者58例,阳性率为63%;CTCs阳性的胃癌患者与肿瘤浸润深度、脉管侵犯、神经侵犯都具有相关性(P=0.02);术后1周60.5%患者CTCs消失或减少,CTCs数量没有变化甚至增多者主要见于TNM分期晚(Ⅳ期)患者。结论 胃癌患者外周血中CTCs与其临床病理分期具有密切相关性。
关键词:  胃癌  循环肿瘤细胞  肿瘤病理分期  胃癌根治术  临床研究
DOI:10.16118/j.1008-0392.2020.01.008
投稿时间:2019-08-07
基金项目:上海市科学技术委员会项目(16411970800);浙江省嘉兴市科技局课题项目(2015AY23071)
Correlation of perioperative circulating tumor cells with clinicopathologic features of gastric cancer patients
GE Hai-yan,ZHANG Zhen-yu,MAO Li-ling,JI Fang,ZHU Zhe,GAO Wei,FU Zheng-wei
(Dept. of Gastrointestinal Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120, China; Second People’s Hospital, Pinghu 314200, Zhejiang Province, China;Nanxiang Community Health Service Center, Jiading District, Shanghai 201802, China)
Abstract:
Objective To investigate the correlation of perioperative circulating tumor cells(CTCs) with clinicopathologic features in gastric cancer patients. Methods The circulating tumor cells were detected with micro-fluid chip technique in 92 gastric cancer patients at 1 day before operation and 1 week after operation. The relationship between the CTCs and tumor clinicopathologic features of patients was analyzed. Results The positive CTCs were detected in 58 cases(63%) 1 day before operation. The positive CTCs were significantly correlated with cancer infiltration depth, blood vessel infiltration, and nerve infiltration(P=0.02). The CTCs was negative or decreased in 60.5% of patients after 1 week of operation. The CTCs were increased or not changed mainly in TNM stage Ⅳ patients. Conclusion The positive CTCs in gastric cancer patients are closely correlated with clinicopathologic features.
Key words:  gastric cancer  circulating tumor cells  tumor pathologic stages  radical resections for gastric cancer  clinical research

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