| 引用本文： |
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陈胜芳,陈昱颉,冯 煜,等.老年患者血清SOD水平与心肾功能的关系[J].同济大学学报（医学版）,2019,40(5):618-623. [点击复制]
- CHEN Sheng-fang,CHEN Yu-jie,Feng Yu,et al.Association of serum superoxide dismutase level with cardiac and renal function in elderly patients[J].同济大学学报（医学版）,2019,40(5):618-623. [点击复制]
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| 摘要: |
| 目的 了解老年患者血清超氧化物歧化酶（superoxide dismutase, SOD）水平，探讨血清SOD与心肾功能的关系。方法 采用横断面调查研究方法，连续纳入符合观察条件的老年患者860例，进行人体测量和生活方式调查，检测血清SOD水平、脑钠肽（brain natriuretic peptide, BNP）、C-反应蛋白（C-reactive protein, CRP）、白蛋白（albumin, Alb）等生化指标,应用Logistic回归法分析血清SOD水平与心肾功能的关系。结果 以血清SOD四分位水平分析各临床指标，发现随着年龄、CRP和BNP水平的升高（F=38.443，P＜0.001；χ2=75.169，P＜0.001；F=39.019，P＜0.001）和血清Alb水平、肾功能的下降（F=137.415，P＜0.001；F=28.037，P＜0.001），血清SOD水平呈下降趋势。与高四分位血清SOD水平比较，校正年龄、性别和传统风险因素后，第2四分位和第1四分位SOD水平发生心功能不全的风险增加（OR=1.86，95%CI： 1.18～2.92；OR=3.15，95%CI： 1.95～5.08）；继续校正血清Alb后，只有第1四分位SOD水平心功能不全的风险增加（OR=1.90，95%CI： 1.11～3.27）；进一步校正CRP后，第1四分位心功能不全风险较弱（OR=1.79，95%CI： 1.00～3.19）。与高四分位血清SOD水平比较，校正年龄、性别和传统风险因素后，第2四分位和第1四分位SOD水平发生肾功能不全的风险增加（OR=2.43，95%CI： 1.51～3.90；OR=2.86，95%CI： 1.77～4.63）；继续校正Alb和CRP水平后，第2四分位和第1四分位SOD水平发生肾功能不全的风险进一步增加（OR=3.14，95%CI： 1.82～5.40；OR=4.21，95%CI： 2.30～7.70）。结论 老年人血清SOD水平随着年龄增加呈下降趋势；血清SOD水平下降与心肾功能降低有关，是影响肾功能的重要因素。 |
| 关键词: 老年人 超氧化物歧化酶 脑钠肽 估计肾小球滤过率 C-反应蛋白 |
| DOI：10.16118/j.1008-0392.2019.05.016 |
| 投稿时间：2019-02-24 |
| 基金项目: |
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| Association of serum superoxide dismutase level with cardiac and renal function in elderly patients |
| CHEN Sheng-fang,CHEN Yu-jie,Feng Yu,WU Ping,CUI Chun-li |
| (Dept. of Nutrition, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Dept. of Nutrition, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China;Dept. of Nephrology, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Objective To explore the association of serum superoxide dismutase (SOD）level with cardiac and renal function in elderly patients. Methods In this cross-sectional study 860 consecutive elderly patients were recruited. Anthropometric measurement and lifestyle survey were performed and serum SOD, brain natriuretic peptide (BNP), C-reactive protein (CRP) and albumin were measured. The association between level of serum SOD and cardiac, renal function were analyzed by Logistic regression. Results The quartile of serum SOD level showed a declining trend as the increase of age, CRP and BNP levels as well as the decrease of serum albumin and renal function (F=38.443, P＜0.001; χ2=75.169, P＜0.001; F=39.019, P＜0.001; F=137.415, P＜0.001; F=28.037, P＜0.001). Compared with the highest SOD quartiles, after adjustment for age, gender and traditional risk factors for cardiovascular disease, the risk of cardiac insufficiency was higher both in quartile 2 and quartile 1 (OR=1.86,95%CI: 1.18-2.92; OR=3.15,95%CI: 1.95-5.08). However, After adjustment for serum albumin, only the first quartile SOD patients had an increased risk of cardiac insufficiency (OR=1.90,95% CI: 1.11-3.27); after further adjustment for CRP, the first quartile showed a risk of cardiac insufficiency (OR=1.79,95% CI: 1.00-3.19). After adjustment for age, gender and traditional risk factors, compared with the highest SOD quartiles, the higher risk of renal insufficiency in both quartile 2 and quartile 1 (OR=2.43,95%CI :1.51-3.90; OR=2.86,95%CI: 1.77-4.63). After further adjustment for Alb and CRP levels, the risk of renal insufficiency was still higher both in quartile 2 and quartile 1 (OR=3.14,95%CI: 1.82-5.40; OR=4.21,95%CI: 2.30-7.70). Conclusions The serum SOD level is declined with age in elderly patients. The reduced of serum SOD level is an important factor affecting cardiac and renal function, especially during the progress of renal dysfunction. |
| Key words: elderly superoxide dismutase brain natriuretic peptide estimated glomerular filtration rate C-reactive protein |
