| 摘要: |
| 肉毒毒素（botulinum toxin， BT）是肉毒梭状芽孢杆菌在缺氧条件下产生的神经毒素，通过抑制周围神经末梢的递质释放达到化学性去神经支配作用，已广泛应用于多种疾病的治疗及医学美容等领域。近年来，随着对BT结构、作用机制及生物学特性研究的不断深入，多种各具特色的新型BT正在积极研发中，其对中枢神经系统的潜在影响亦受到越来越多的关注。原有上市药物的循证医学证据级别不断提升，新适应证层出不穷。本文就BT的基础研究及临床应用现状进行分析，为进一步开展相关研究奠定基础。 |
| 关键词: 肉毒毒素 机制 治疗 应用 |
| DOI：10.16118/j.1008-0392.2019.05.001 |
| 投稿时间：2019-07-08 |
| 基金项目:国家重点研发计划（2018YFC1314700）；上海市市级医疗卫生优秀学科带头人培养计划（2017BR029） |
|
| Progress in research and development of botulinum toxin |
| JIN Ling-jing,PAN Li-zhen |
| (Dept. of Neurology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China) |
| Abstract: |
| Botulinum toxin（BT） is produced by clostridial bacteria, which can reduce the release of neurotransmitters, inducing chemodenervation at peripheral nerve terminals. Now BT is widely used in disease treatment and medical cosmetics. With the increasing understanding of its structure, molecular mechanism and biological property, a variety of new BT products with different characteristics have been emerging and its potential effects on central nerve system are concerned. The evidence levels of market-available BT products have been upgraded and the new indications have been expanded. In this article, we review the current progress in basic research and clinical application of BT to provide new information for researchers and clinicians. |
| Key words: botulinum toxin mechanism therapy application |
