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  • 王路鑫,黄 建,张杨杨,等.环状RNA在心血管系统中的表达与功能[J].同济大学学报(医学版),2019,40(4):507-515.    [点击复制]
  • WANG Lu-xin,HUANG Jian,ZHANG Yang-yang,et al.Expression and function of circular RNAs in the cardiovascular system[J].同济大学学报(医学版),2019,40(4):507-515.   [点击复制]
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环状RNA在心血管系统中的表达与功能
王路鑫,黄建,张杨杨,陈义汉
0
(南京医科大学上海东方临床医学院,南京 210029;同济大学心律失常教育部重点实验室,上海 200092)
摘要:
环状RNA(circular RNAs,circRNAs)是一类首尾通过共价键衔接构成封闭环状的单链RNA分子。与线性的RNA分子不同,它没有5′端帽子和3′ 端poly(A)尾巴,传统的RNA检测手段不易识别。高通量测序技术的应用及日益成熟使得人们逐渐认识到circRNAs在哺乳动物各组织大量、稳定存在,并在多种疾病的发生发展过程中起着重要的作用。本文就circRNAs的生物合成、功能和其在心血管疾病发生发展中的作用及机制进行综述。
关键词:  环状RNA  心血管疾病  生物合成  生物学标志物
DOI:10.16118/j.1008-0392.2019.04.020
投稿时间:2019-06-28
基金项目:国家自然科学基金面上项目(81770397)
Expression and function of circular RNAs in the cardiovascular system
WANG Lu-xin,HUANG Jian,ZHANG Yang-yang,CHEN Yi-Han
(Shanghai East Hospital of Clinical Medical College, Nanjing Medical University, Nanjing 210029, China; Key Laboratory of Arrhythmias of the Ministry of Education of China,Tongji University School of Medicine, Shanghai 200092, China)
Abstract:
Circular RNAs (circRNAs) are covalently closed, single-stranded RNA molecules produced by back-splicing from precursor mRNA (pre-mRNA). Unlike linear RNA molecules, circRNAs lack 5′ end caps and 3′ end poly (A) tails and are difficult to be detected by conventional methods of RNA analysis. Now, high-throughput sequencing has revealed the stable existence of abundant circRNAs in a variety of mammalian tissues, and it plays important roles in numerous diseases. Herein, we review the biogenesis and functions of circRNAs, with particular focus on their roles in cardiovascular diseases.
Key words:  circular RNAs  cardiovascular disease  biogenesis  biomarker

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