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  • 黄大祥,李梦媛,彭 艾,等.尿酸排泄分数与肾功能关系的研究[J].同济大学学报(医学版),2019,40(4):448-453.    [点击复制]
  • HUANG Da-xiang,LI Meng-yuan,PENG Ai,et al.Relationship between urinary fractional excretion of uric acid and renal function in patients with chronic kidney disease[J].同济大学学报(医学版),2019,40(4):448-453.   [点击复制]
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尿酸排泄分数与肾功能关系的研究
黄大祥,李梦媛,彭艾,秦岭
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(同济大学附属第十人民医院崇明分院肾脏科,上海 202150;同济大学附属第十人民医院肾脏风湿科,上海 200072)
摘要:
目的 探讨慢性肾脏病患者中,尿酸排泄分数与肾功能的关系。方法 搜集检测24h尿相关指标的慢性肾脏病患者245例,根据尿酸排泄分数(fraction excretion of uric acid, FEUA)的四分位数间距分为4组(FEUA 1~4),分析尿酸排泄分数与肾功能的关系。运用相关性分析,研究FEUA与预估肾小球滤过率(eGFR)、24h尿蛋白的关系。采用Logistic回归方法分析各临床指标与肾功能的关系。结果 随着FEUA的逐渐升高,eGFR逐渐降低;而且FEUA与eGFR负相关(r=-0.591, P<0.0001);FEUA与24h尿蛋白正相关(r=0.408,P<0.0001)。Logistic回归表明,FEUA与肾功能相关(OR=1.085,95%CI=1.008~1.167,P=0.035)。结论 在慢性肾脏病患者,FEUA是肾功能的危险因素;而且FEUA水平越高,肾功能越差。
关键词:  慢性肾脏病  尿酸排泄分数  肾功能  肾小球滤过率  尿蛋白
DOI:10.16118/j.1008-0392.2019.04.010
投稿时间:2018-10-08
基金项目:上海市崇明区“可持续发展科技创新行动计划”(CKY2018-24)
Relationship between urinary fractional excretion of uric acid and renal function in patients with chronic kidney disease
HUANG Da-xiang,LI Meng-yuan,PENG Ai,QIN Ling
(Dept. of Nephrology, Tenth People’s Hospital Chongming Branch, Tongji University School of Medicine, Shanghai 202150, China;Dept. of Nephrology & Rheumatology, Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China)
Abstract:
Objective To investigate the relationship between urinary fractional excretion of uric acid (FEUA) and renal function in patients with chronic kidney disease (CKD). Methods Two hundred and forty-five CKD patients were enrolled in the study and 24-h-urine parameters were collected. According to the quartile of FEUA, patients were classified into FEUA 1-4 groups. The relationship between EFUA and estimated glomerular filtration rate (eGFR), and 24h urinary protein were analyzed with Spearman correlation analysis; and the association of renal function with clinical parameters was analyzed with multiple Logistic regression analysis. Results The FEUA level was negatively correlated with eGFR (r=-0.591, P<0.0001) and positively correlated with 24h urinary protein (r=0.408,P<0.0001) in CKD patients. The multiple Logistic regression analysis indicated that FEUA was an independent risk factor for decreased renal function (OR=1.085,95%CI=1.008-1.167, P=0.035). Conclusion Higher urinary fractional excretion of uric acid is associated with a worse renal function in patients with chronic kidney disease.
Key words:  chronic kidney disease  excretion fraction of uric acid  renal function glomerular filtration rate  urinary protein

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