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  • 梅芳芸,尹嘉晶,周东雷,等.袖状胃切除术对甲状腺功能正常的肥胖患者甲状腺功能的影响[J].同济大学学报(医学版),2019,40(4):441-447.    [点击复制]
  • MEI Fang-yun,YIN Jia-jing,ZHOU Dong-lei,et al.Effect of sleeve gastrectomy on thyroid function in obese euthyroid patients[J].同济大学学报(医学版),2019,40(4):441-447.   [点击复制]
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袖状胃切除术对甲状腺功能正常的肥胖患者甲状腺功能的影响
梅芳芸,尹嘉晶,周东雷,卢列盛,曲伸
0
(同济大学附属第十人民医院内分泌及代谢病科,上海 200072;同济大学附属第十人民医院糖尿病减重代谢外科,上海 200072)
摘要:
目的 观察腹腔镜下袖状胃切除术(laparoscpic sleeve gastrectomy, LSG)对甲状腺功能正常的肥胖患者甲状腺功能的影响。方法 纳入2012年12月—2018年5月在同济大学附属第十人民医院进行LSG手术的甲状腺功能正常的51名肥胖患者为研究对象,以促甲状腺激素(thyroid stimulating hormone, TSH)=2.5mIU/L为切点,将其分为正常TSH组(A组: 0.38~2.5mIU/L)和高TSH组(B组: 2.5~4.34mIU/L)。收集两组LSG术前、术后6个月的身高、体质量、甲状腺功能相关数据;采用双能X线吸收法测定身体各部位脂肪含量。结果 LSG术后6个月A组TSH降低无统计学意义(P=0.855),而B组TSH降低有统计学意义(P<0.05)。Pearson相关分析结果显示,女性和B组肥胖患者ΔTSH与ΔBMI、总体质量减少百分比以及多余体质量减少百分比呈显著的正相关(均0
关键词:  袖状胃切除术  肥胖  甲状腺功能  促甲状腺激素  体脂分布
DOI:10.16118/j.1008-0392.2019.04.009
投稿时间:2018-11-04
基金项目:市级医院新兴前沿技术联合攻关项目(SHDC12015127)
Effect of sleeve gastrectomy on thyroid function in obese euthyroid patients
MEI Fang-yun,YIN Jia-jing,ZHOU Dong-lei,LU Lie-sheng,QU Shen
(Dept. of Endocrinology and Metabolism, Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China;Dept. of Bariatric Surgery, Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China)
Abstract:
Objective To investigate the effect of laparoscopic sleeve gastrectomy (LSG) on thyroid function in obese euthyroid patients. Methods Fifty-one obese patients with normal thyroid function who underwent LSG operation in Shanghai Tenth People’s Hospital from December 2012 to May 2018 were enrolled in the study. There were 27 patients with normal TSH levels (group A, 0.38-2.5mIU/L) and 24 patients with high TSH levels (group B, 2.5-4.34mIU/L). The height, weight and thyroid function were measured before and 6 months after LSG in two groups fat content was measured by dual-energy X-ray absorptiometry (DEXA). Results Compare to those before operation, the TSH levels 6 months after LSG in group A were not significantly changed(P=0.855), but the TSH levels were significant decreased in group B(P<0.05). Pearson correlation analysis showed that ΔTSH was positively correlated with ΔBMI, total weight loss (% TWL) and excess weight loss (% EWL) in group B and female patients (all 0
Key words:  laparoscopic sleeve gastrectomy  obesity  thyroid function  thyroid stimulating hormone  body fat distribution

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