| 引用本文： |
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郑昌月,张 娟,牛国桢,等.改良碘凝胶泪道造影剂的研制[J].同济大学学报（医学版）,2019,40(4):436-440. [点击复制]
- ZHENG Chang-yue,ZHANG Juan,NIU Guo-zhen,et al.Development of modified iodine gel lacrimal contrast agent[J].同济大学学报（医学版）,2019,40(4):436-440. [点击复制]
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| 摘要: |
| 目的 研制一种用于阻塞性泪道疾病的改良泪道造影剂。方法 使用碘帕醇注射液（碘浓度37g/100mL，粘度25mPa·s）与氧氟沙星眼用凝胶（黏度为8400mPa·s）按照1∶1比例混合，共计80mL混合碘剂（混合物粘度为550mPa·s），在生物安全柜中恒温脱水，至体积约为40mL碘凝胶。结果 配制的碘凝胶黏度为350mPa·s，碘浓度为37g/100mL。以长针后退注射法将碘凝胶注射入患者泪道，320排螺旋CT扫描泪道，能获得清晰的泪道断面图，辅以CT三维成像技术可建立泪道三维图，能进一步了解泪道解剖情况以及阻塞部位与程度。结论 改良碘凝胶泪道造影剂泪道充盈良好，维持时间充分，CT成像效果好。 |
| 关键词: 泪道阻塞 泪道造影 CT 断层扫描 三维重建 造影剂 |
| DOI：10.16118/j.1008-0392.2019.04.008 |
| 投稿时间：2018-11-12 |
| 基金项目:上海市申康医院发展中心专科疾病临床“五新”转化项目（16CR3027A）；上海市卫生系统优秀学科带头人培养计划（2017BR060）；上海市普陀区高层次人才科研创新项目（2014-A-25） |
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| Development of modified iodine gel lacrimal contrast agent |
| ZHENG Chang-yue,ZHANG Juan,NIU Guo-zhen,WANG Zhen,Hou-shuo,BI Yan-long |
| (Dept. of Ophthalmology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China) |
| Abstract: |
| Objective To develop a new modified lacrimal contrast agent for obstructive lacrimal disease. Methods Iopamidol injection (iodine concentration 37g/100mL, viscosity 25mPa·s) and ofloxacin ophthalmic gel (viscosity 8400mPa·s) were mixed in a 1∶1 ratio into a total of 80mL iodine gel (mixture viscosity 550mPa·s). Then the iodine gel was dehydrated with constant temperature in biosafety cabinet to a volume of about 40mL. Results The iodine gel with the viscosity of 350mPa·s and iodine concentration of 37g/100mL was injected into the lacrimal passage of the patient. Then the lacrimal passage was scanned with 320-row spiral CT. The clear lacrimal duct profile was obtained, and the three-dimensional imaging of the lacrimal passage was constructed by CT 3-D imaging technique. Conclusion The modified iodine gel lacrimal contrast agent prepared in this study has good lacrimal filling, sufficient maintenance time and good CT imaging effect. |
| Key words: lacrimal duct obstruction lacrimal angiography CT tomography three-dimensional reconstruction contrast agent |
