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  • 郑昌月,张 娟,牛国桢,等.改良碘凝胶泪道造影剂的研制[J].同济大学学报(医学版),2019,40(4):436-440.    [点击复制]
  • ZHENG Chang-yue,ZHANG Juan,NIU Guo-zhen,et al.Development of modified iodine gel lacrimal contrast agent[J].同济大学学报(医学版),2019,40(4):436-440.   [点击复制]
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改良碘凝胶泪道造影剂的研制
郑昌月,张娟,牛国桢,王震,李厚硕,毕燕龙
0
(同济大学附属同济医院眼科,上海 200065)
摘要:
目的 研制一种用于阻塞性泪道疾病的改良泪道造影剂。方法 使用碘帕醇注射液(碘浓度37g/100mL,粘度25mPa·s)与氧氟沙星眼用凝胶(黏度为8400mPa·s)按照1∶1比例混合,共计80mL混合碘剂(混合物粘度为550mPa·s),在生物安全柜中恒温脱水,至体积约为40mL碘凝胶。结果 配制的碘凝胶黏度为350mPa·s,碘浓度为37g/100mL。以长针后退注射法将碘凝胶注射入患者泪道,320排螺旋CT扫描泪道,能获得清晰的泪道断面图,辅以CT三维成像技术可建立泪道三维图,能进一步了解泪道解剖情况以及阻塞部位与程度。结论 改良碘凝胶泪道造影剂泪道充盈良好,维持时间充分,CT成像效果好。
关键词:  泪道阻塞  泪道造影  CT 断层扫描  三维重建  造影剂
DOI:10.16118/j.1008-0392.2019.04.008
投稿时间:2018-11-12
基金项目:上海市申康医院发展中心专科疾病临床“五新”转化项目(16CR3027A);上海市卫生系统优秀学科带头人培养计划(2017BR060);上海市普陀区高层次人才科研创新项目(2014-A-25)
Development of modified iodine gel lacrimal contrast agent
ZHENG Chang-yue,ZHANG Juan,NIU Guo-zhen,WANG Zhen,Hou-shuo,BI Yan-long
(Dept. of Ophthalmology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China)
Abstract:
Objective To develop a new modified lacrimal contrast agent for obstructive lacrimal disease. Methods Iopamidol injection (iodine concentration 37g/100mL, viscosity 25mPa·s) and ofloxacin ophthalmic gel (viscosity 8400mPa·s) were mixed in a 1∶1 ratio into a total of 80mL iodine gel (mixture viscosity 550mPa·s). Then the iodine gel was dehydrated with constant temperature in biosafety cabinet to a volume of about 40mL. Results The iodine gel with the viscosity of 350mPa·s and iodine concentration of 37g/100mL was injected into the lacrimal passage of the patient. Then the lacrimal passage was scanned with 320-row spiral CT. The clear lacrimal duct profile was obtained, and the three-dimensional imaging of the lacrimal passage was constructed by CT 3-D imaging technique. Conclusion The modified iodine gel lacrimal contrast agent prepared in this study has good lacrimal filling, sufficient maintenance time and good CT imaging effect.
Key words:  lacrimal duct obstruction  lacrimal angiography  CT tomography  three-dimensional reconstruction  contrast agent

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