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引用本文：

李苑,王宇彤,徐越,等.细胞衰老与肿瘤发生[J].同济大学学报（医学版）,2019,40(3):388-391,396. [点击复制]
LI Yuan,WANG Yu-tong,XU Yue,et al.Cellular Senescence and Tumorigenesis[J].同济大学学报（医学版）,2019,40(3):388-391,396. [点击复制]

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细胞衰老与肿瘤发生
李苑,王宇彤,徐越,俞作仁
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(同济大学附属东方医院转化医学研究中心，上海 200120;锦州医科大学基础医学院系，锦州 121001;同济大学生命科学院，上海 200092)

摘要:

人口老龄化和恶性肿瘤高发，已成为我国健康领域的两大社会问题。氧自由基学说和端粒学说是引起细胞衰老的主要原因，而衰老引起基因突变积累、炎性反应和免疫功能低下等等，进一步诱导肿瘤发生。因此，了解细胞衰老和肿瘤发生的调控机制，以及二者之间的相互关系，对于临床肿瘤治疗和抗衰老具有重要意义。

关键词: 衰老肿瘤自由基端粒

DOI：10.16118/j.1008-0392.2019.03.023

投稿时间：2018-12-24

基金项目:科技部“干细胞及转化研究”国家重点研发计划(2016YFA0101202)；江西省自然科学基金（20181BAB205001）；国家自然科学基金(81400070)

Cellular Senescence and Tumorigenesis

LI Yuan,WANG Yu-tong,XU Yue,YU Zuo-ren

(Research Center for Translational Medicine, East Hospital, Tongji University, Shanghai 200120, China;Research Center for Translational Medicine, East Hospital, Tongji University, Shanghai 200120, China; College of Basic Medical Sciences, Jinzhou Medical University, Jinzhou 121001, China;College of Life Science, Tongji University, Shanghai 200092, China)

Abstract:

Aging and increasing incidence of cancer are two main social issues nowadays in China. Oxygen free radical and telomere are two of the widely-recognized theories causing aging. The gene mutations, inflammatory reactions and immune dysfunction caused by aging, have been well demonstrated to induce tumorigenesis. Therefore, understanding the mechanisms regulating aging and tumorigenesis, and the relationship between aging and tumorigenesis, will shed light on developing strategies for suppressing tumor growth and anti-aging.

Key words: aging tumorigenesis oxygen free radical teleomere