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  • 王雅平,洪 军,王 健,等.伴神经内分泌分化胃癌远处转移危险因素分析[J].同济大学学报(医学版),2019,30(3):349-355.    [点击复制]
  • WANG Ya-ping,HONG Jun,WANG Jian,et al.Risk factors of distant metastasis in patients with gastric cancer accompanying neuroendocrine cell differentiation[J].同济大学学报(医学版),2019,30(3):349-355.   [点击复制]
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伴神经内分泌分化胃癌远处转移危险因素分析
王雅平,洪军,王健,贝一冰,华鲁纯,蒿汉坤
0
(复旦大学附属华山医院普外科,上海 200040)
摘要:
目的 分析伴神经内分泌分化(neuroendocrine cell differentiation, NED)胃癌发生远处转移的相关危险因素。方法 回顾性分析71例复旦大学附属华山医院于2007年1月—2018年8月期间行手术根治且病理确诊为伴神经内分泌分化胃癌患者的临床、病理及术后随访资料,分析其与肿瘤远处转移的相关性。结果 单因素及多因素Cox回归分析示肿瘤浸润深度(≥T3)、淋巴结转移数(≥4枚)、术中出血量(≥300mL)是肿瘤远处转移的独立影响因素(P<0.05)。结论 原发肿瘤浸润深度、区域淋巴结转移、术中出血量是影响胃癌伴NED患者远处转移的相关因素。
关键词:  胃癌  神经内分泌分化  转移
DOI:10.16118/j.1008-0392.2019.03.016
投稿时间:2019-03-03
基金项目:国家自然科学基金青年项目(81802901)
Risk factors of distant metastasis in patients with gastric cancer accompanying neuroendocrine cell differentiation
WANG Ya-ping,HONG Jun,WANG Jian,BEI Yi-bing,HUA Lu-chun,HAO Han-kun
(Dept. of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China)
Abstract:
Objective To analyze the risk factors of distant metastasis in patients with gastric cancer accompanying neuroendocrine cell differentiation (NED). Methods Clinicopathological data of 71 gastric cancer patients with NED who received gastrectomy in Huashan Hospital Fudan University from January 2007 to August 2018 were reviewed retrospectively. The risk factors of distant metastasis were analyzed with univariate and multivariate regression. Results Univariate and multivariate analysis showed that infiltration depth ≥T3, lymph nodes metastasis ≥4 and intraoperative bleeding volume≥300mL were independent positive factors of distant metastasis (P<0.05). Conclusion Tumor infiltration depth, the number of lymph nodes metastasis and the volume of intraoperative bleeding may increase the risk of distant metastasis of gastric cancer accompanying NED.
Key words:  gastric cancer  neuroendocrine cell differentiation  metastasis

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