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罗晶,陈冠楠,吕欣.右美托咪定对单肺通气时氧合功能影响的研究进展[J].同济大学学报（医学版）,2018,39(4):129-132. [点击复制]
LUO Jing1,2, 2, 1,2,CHEN Guan-nan,L? Xin.Progress on the effect of dexmedetomidine on oxygenation during one-lung ventilation[J].同济大学学报（医学版）,2018,39(4):129-132. [点击复制]

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右美托咪定对单肺通气时氧合功能影响的研究进展
罗晶,陈冠楠,吕欣
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(江苏省麻醉学重点实验室，江苏省麻醉与镇痛应用技术重点实验室，徐州医科大学江苏徐州221000; 同济大学附属上海市肺科医院麻醉科，上海200433)

摘要:

单肺通气时容易发生低氧血症，不利于患者的预后。近年来，大量的研究发现右美托咪定通过作用缺氧性肺血管收缩、氧耗、心输出量和炎症等因素影响单肺通气中的氧合。本文就单肺通气时右美托咪定对氧合功能的影响进行综述。

关键词: 右美托咪定单肺通气低氧血症氧合

DOI：10.16118/j.1008-0392.2018.04.025

投稿时间：2017-04-20

基金项目:国家自然科学基金(81671947)；上海市科委引导项目（14401932500）；上海市科委产学研项目（16DZ1930307）

Progress on the effect of dexmedetomidine on oxygenation during one-lung ventilation

LUO Jing1,2, 2, 1,2,CHEN Guan-nan,L? Xin

(Jiangsu Provincial Key Laboratory of Anesthesiology, Jiangsu Provincial Key Laboratory of Anesthesiology and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221000, Jiangsu, China; Dept. of Anesthesiology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China)

Abstract:

One-lung ventilation (OLV) can predispose to hypoxemia, which severely affects the prognosis of patients. There is increasing evidence supporting that the effect of dexmedetomidine on oxygenation during OLV by influencing hypoxic pulmonary vasoconstriction (HPV), oxygen consumption, cardiac output and inflammation. This review focuses on the effect of dexmedetomidine on oxygenation during OLV.

Key words: dexmedetomidine one-lung ventilation hypoxemia oxygenation