| 引用本文： |
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姜姗,严骅,张勤华,等.克罗米芬温和刺激方案全胚冷冻后首次冻融胚胎移植时间对临床结局的影响[J].同济大学学报（医学版）,2017,38(3):94-97. [点击复制]
- JIANG Shan,YAN Hua,ZHANG Qin-hua,et al.Effect of time from egg retrieval to subsequent frozen-thawed embryo transfer on clinical outcomes with clomiphene citrate mild stimulation protocol[J].同济大学学报（医学版）,2017,38(3):94-97. [点击复制]
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| 摘要: |
| 目的 探讨克罗米芬温和刺激方案全胚冷冻后,首次冻融胚胎移植(frozen-thawed embryo transfer, FET)时间选择对治疗结局的影响。方法 回顾性分析262例克罗米芬温和刺激方案全胚冷冻周期患者资料,应用激素替代方案行首次FET。根据首次FET时间将患者分为3组,C1组(n=94): 取卵后第1次月经周期,C2组(n=86): 取卵后第2次月经周期,C3组(n=82): 取卵后第3次及此后月经周期。比较3组一般情况及FET临床结局相关指标。结果 3组患者年龄(P=0.205)、BMI(P=0.904)、克罗米芬应用时间(P=0.355)、克罗米芬总量(P=0.095)、获卵数(P=0.503)、受精率(P=0.314)、有效胚胎数(P=0.265)、优质胚胎数(P=0.084)、移植日内膜厚度(P=0.423)、移植胚胎数(P=0.198)比较,差异均无统计学意义。3组患者的临床妊娠率(P=0.507)、种植率(P=0.499)、继续妊娠率(P=0.512)、活产率(P=0.720)比较,差异均无统计学意义。结论 克罗米芬温和刺激方案全胚冷冻后首次FET时间的选择对临床结局无明显影响,可尽早行FET。 |
| 关键词: 温和刺激 克罗米芬 全胚冷冻 冻融胚胎移植 |
| DOI：10.16118/j.1008-0392.2017.03.019 |
| 投稿时间：2017-03-07 |
| 基金项目: |
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| Effect of time from egg retrieval to subsequent frozen-thawed embryo transfer on clinical outcomes with clomiphene citrate mild stimulation protocol |
| JIANG Shan,YAN Hua,ZHANG Qin-hua,TONG Guo-qing |
| (Center of Reproductive Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China) |
| Abstract: |
| ObjectiveTo explore the effect of the time from ovum pick-up (OPU) to subsequent frozen-thawed embryo transfer (FET) on clinical outcomes in patients receiving clomiphene citrate mild stimulation protocol and freeze-all strategy. Methods Data of 262 freeze-all cycles were retrospectively analyzed. Controlled ovarian hyperstimulation (COH) was performed by mild stimulation protocol with clomiphene citrate. Endometrial preparation was performed in an artificial cycle. Reproductive outcomes among FETs which took place within the first menstrual cycle following OPU (C1, n=94), the second menstrual cycle following OPU (C2, n=86),or afterwards (C3,n=82 ) were compared. Results The differences of age (P=0.205),BMI(P=0.904),the total amount of clomiphene citrate (P=0.095) and stimulation period (P=0.355),the number of retrieved oocytes (P=0.503),fertilization rate(P=0.314)and obtained embryos (P=0.265),endometrial thickness (P=0.423) and the number of embryos transferred (P=0.198) on transfer day were not statistically significant among the three groups. There was no difference for clinical pregnancy rate (P=0.507),implantation rate (P=0.499),continued pregnancy rate (P=0.512) and live birth rate (P=0.720) among the three groups. Conclusion The time from OPU to FET does not affect the outcomes in patients receiving mild stimulation protocol with clomiphene citrate. |
| Key words: mild stimulation protocol clomiphene citrate freeze-all frozen-thawed embryo transfer |
