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徐婷婷,张峰,张雪丽,等.定量动态增强磁共振成像预测乳腺癌分子亚型的价值[J].同济大学学报（医学版）,2017,38(3):50-55. [点击复制]
XU Ting-ting,ZHANG Feng,ZHANG Xue-li,et al.Association between quantitative parameters of DCE-MRI and molecular subtypes of breast cancer[J].同济大学学报（医学版）,2017,38(3):50-55. [点击复制]

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定量动态增强磁共振成像预测乳腺癌分子亚型的价值
徐婷婷,张峰,张雪丽,万丽娣,华婷,汤光宇
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(同济大学附属第十人民医院放射科,上海 200072)

摘要:

目的研究乳腺癌动态增强磁共振成像(dynamic contrast-enhanced magnetic resonance imaging, DCE-MRI)定量参数与其分子分型的相关性。方法回顾性分析经手术病理证实102例不同分子亚型乳腺癌DCE-MRI定量参数,包括容量转移常数(K^trans)、速率常数(K_ep)和血管外细胞外间隙容积比(V_e)。记录瘤体免疫组织化学的雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子受体-2(HER-2)及Ki67的表达情况,比较不同分子分型乳腺癌DCE-MRI定量参数的差异,分析生物学预后因子表达与DCE-MRI定参数的相关性。结果不同分子亚型乳腺癌的DCE-MRI定量参数(K^trans、K_ep、V_e)差异没有统计学意义(H=5.416,P=0.175；H=4.926,P=0.177；H=4.203,P=0.240)；ER、PR阴性组的K^trans及K_ep值高于ER、PR阳性组；HER2阳性组的K_ep值高于HER2阴性组(P<0.05),但二组间的K^trans值、V_e值及ADC值差异均无统计学意义(P>0.05)；Ki67高表达组的K^trans、K_ep值均高于Ki67低表达组。结论乳腺癌DCE-MRI定量参数不能预测乳腺癌分子亚型,但部分定量参数与预后因子(ER、PR、HER2、Ki67)表达有相关性；K^trans、K_ep值可以反映乳腺癌的生物学行为,有助于评估乳腺癌预后。

关键词: 动态增强磁共振成像预后因子定量参数

DOI：10.16118/j.1008-0392.2017.03.010

投稿时间：2017-01-22

基金项目:

Association between quantitative parameters of DCE-MRI and molecular subtypes of breast cancer

XU Ting-ting,ZHANG Feng,ZHANG Xue-li,WAN Li-di,HUA Ting,TANG Guang-yu

(Dept. of Radiology, Tenth People's Hospital, Tongji University, Shanghai 200072, China)

Abstract:

Objective To investigate the association between quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and molecular subtypes of breast cancers. Methods The DCE-MRI findings were retrospectively analyzed in 102 patients with pathologically confirmed breast cancer. The volume transfer constant (K^trans), rate constant (K_ep) and volume of EES per unit volume of tissue (V_e) value were calculated. The immunohistochemistry results of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2) and Ki67 were reviewed. The quantitative parameters of DCE-MRI were compared among patients with different immunohistochemical subtype. Results There were no statistically significances in quantitative parameters K^trans, K_ep and V_e among patients with different immunohistochemical subtype(H=5.416,P=0.175；H=4.926,P=0.177；H=4.203,P=0.240, respectively). K^trans and K_ep values were higher in tumors with ER-negative and PR-negative than those with ER-positive and PR-positive. K_epvalue was higher in tumors with HER-2-positive than that with HER-2-negative. There was no significant difference in K^trans and V_e values between HER-2 positive and HER-2 negative tumors (P>0.05). K^trans and K_ep values in tumors with high Ki67 expression were higher than those with low Ki67 expression. Conclusion Different subtypes of breast cancer can not be predicted by using DCE-MRI quantitative parameters. However, there is some correlation between DCE-MRI quantitative parameters and the prognostic factors. K^trans and K_ep values may reflect the biological behavior, which is related to the prognosis of breast cancer.

Key words: dynamic contrast-enhanced magnetic resonance imaging prognostic factors quantitative parameters