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铁金军,周晓慧,范慧敏.乳腺癌缺失基因1作用的研究进展[J].同济大学学报（医学版）,2017,38(2):125-128. [点击复制]
tiejinjun,zhouxiaohui,fanhuimin.Research progress on roles of DBC1 gene in various diseases[J].同济大学学报（医学版）,2017,38(2):125-128. [点击复制]

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乳腺癌缺失基因1作用的研究进展
铁金军,周晓慧,范慧敏
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(同济大学附属东方医院心外科,上海 200120;同济大学附属东方医院心力衰竭研究所,上海 200120)

摘要:

DBC1最早发现是在乳腺癌中杂合性缺失,被称为乳腺癌缺失基因1(deleted in breast cancer 1)。DBC1在基因表达、细胞周期及凋亡、肿瘤发生等过程中均有不同的调节作用。随着研究的不断深入,对DBC1的表达进行调控很可能成为肿瘤,炎症以及代谢性疾病重要的干预靶点。本文对DBC1在肿瘤、淋巴细胞功能和部分代谢性疾病中的作用进行综述。

关键词: 乳腺癌缺失基因1 肿瘤淋巴细胞肥胖症

DOI：10.16118/j.1008-0392.2017.02.026

投稿时间：2016-02-29

基金项目:国家自然科学基金(81470393、81370434、81400363)；上海市领军人才(2012053)；上海市卫计委(ZY3-LCPT-2-1003)；浦东新区卫计委重点学科群建设(PWZxq2014-01)；浦东新区科委(Pkj2013-z03)

Research progress on roles of DBC1 gene in various diseases

tiejinjun,zhouxiaohui,fanhuimin

(Dept.of Cardiac Surgery, East Hospital, Tongji University, Shanghai 200120, China;Research Institute of Heart Failure, East Hospital, Tongji University, Shanghai 200120, China)

Abstract:

Deleted in breast cancer 1(DBC1) gene was first found to be heterozygous for deletion in breast cancer. Recent studies have demonstrated that DBC1 plays different roles in gene expression, cell cycle, apoptosis and tumor occurrence. Therefore, it may be a therapeutic target for cancer, inflammation and metabolic diseases. This review summarized the roles of DBC1 in tumor progression, lymphocytes function and some metabolic diseases.

Key words: deleted in breast cancer 1 tumor lymphocyte obesity