| 摘要: |
| 本文综述了骨骼肌肌母细胞移植的历史和临床研究进展。骨骼肌肌母细胞在治疗遗传性肌肉疾病、缺血性心脏病方面作用突出,但在进一步临床试验中发现,移植后存在肌母细胞损失率高,迁移率低,导致心律失常等不足。除此之外,人类肌母细胞基因移植在治疗糖尿病、癌症等方面有独特的优势。总的来说,骨骼肌肌母细胞移植应用领域广泛,但目前在改善心肌缺血,治疗肌肉营养不良等疾病方面各有利弊,期待更综合的研究攻破移植的限制,从而有效指导临床细胞治疗。 |
| 关键词: 骨骼肌肌母细胞移植 肌肉疾病 缺血性心脏病 基因移植 细胞治疗 |
| DOI：10.16118/j.1008-0392.2016.06.026 |
| 投稿时间：2016-05-04 |
| 基金项目:国家自然科学基金面上项目(81370433) |
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| Progress on clinical application of skeletal myoblasts |
| ZHANG Li-kui,LIU Zhong-min |
| (Dept. of Cardiac Surgery, East Hospital, Tongji University, Shanghai 200120, China) |
| Abstract: |
| This article reviews the history and research progress of myoblast transplantation in clinical application. Skeletal myoblast transplantation has been used to treat hereditary muscle diseases and ischemic heart diseases； however, the complications of arrhythmia, the low survival and migration rate after transplantation inhibited its further clinical application. Human myoblast gene transplantation has the advantages in treatment of diabetes, cancer, and other diseases. Skeletal myoblast transplantation embraces huge potential in clinical applications, which also has benefits and risks in improving myocardial ischemia and treating muscle malnutrition. Ii is expected that more comprehensive researches would be conducted to break through its limitations in near future, so as to be effectively used in clinical cell therapy. |
| Key words: skeletal myoblast transplantation muscle diseases ischemic heart diseases gene transplantation cell therapy |
