LU Ting,ZHANG Yue-hua,LI Wei,et al.Risk factors of non-alcoholic fatty liver disease in patients with Type 2 diabetes mellitus[J].同济大学学报（医学版）,2016,37(5):97-101. [点击复制]
Objective To investigate the risk factors of non-alcoholic fatty liver disease (NAFLD)in patients with type 2 diabetes mellitus(T2DM). Methods One hundred and thirty three T2DM patients admitted in Department of Endocrinology of Shanghai Tenth People's Hospital from June to August 2014 were enrolled in the study, including 63 cases complicated with NAFLD and 77 cases without NAFLD based on clinical diagnosis. The age, gender, duration of T2DM, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), glucose and lipid metabolism, serum enzyme indexes, C-reactive protein (CRP), blood uric acid (BUA) of two groups were analyzed. Bone mineral density (BMD) of the patients was determined by using dual energy X-ray, and the relationship between NAFLD risk factors and bone density was investigated. Results The values of BMI, SBP, DBP, TG and BUA in T2DM patients with NAFLD were significantly higher than those of T2DM patients without NAFLD, while the value of HDL-C was significantly lower than that of non-NAFLD patients. The rates of increased CRP (>8.2mg/L) in T2DM patients with and without NAFLD were 38.1%(24/63)and 17.1%(12/70), respectively(χ2=7.374,P=0.007). Non-conditional logistic regression analysis showed that BMI and HDL-C were risk factors of NAFLD in T2DM patients (OR= 1.190 and 0.227. 95% CI: 1.045-1.354 and 0.058-0.896, P＜0.01 and 0.05).There were no significant differences in BMD of L1-L4, right hip and femoral neck between T2DM patients with NAFLD and those without NAFLD. Conclusion High BMI and low HDL-C are the main risk factors of T2DM complicated with NAFLD, but the bone mineral density is not associated with NAFLD in T2DM patients.
