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靳霞,梁俊华,高浩,等.盐酸羟考酮注射液在取环手术中的止痛作用和安全性研究[J].同济大学学报（医学版）,2016,37(5):85-88. [点击复制]
JIN Xia,LIANG Jun-hua,GAO Hao,et al.Analgesic effect and safety of oxycodone hydrochloride injection in extraction of intrauterine device[J].同济大学学报（医学版）,2016,37(5):85-88. [点击复制]

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盐酸羟考酮注射液在取环手术中的止痛作用和安全性研究
靳霞,梁俊华,高浩,王建军,高阗
0 字体:加大+\|默认\|缩小-
(同济大学附属同济医院妇产科,上海 200065)

摘要:

目的观察盐酸羟考酮注射液用于取环手术的止痛效果和安全性。方法将2015年7月到10月进行取环手术的患者,根据是否应用盐酸羟考酮注射液镇痛随机分为实验组及对照组,各37例,实验组术前5min静脉注射盐酸羟考酮注射液,对照组术前5min静脉注射生理盐水；分析两组患者的一般资料、术前、术中及术后5min的平均动脉压、心率、血氧饱和度、术中出血、手术时间及不良反应等。应用视觉模拟评分(visual analogue scale, VAS)观察术中盐酸羟考酮注射液的镇痛效果。结果与对照组相比,实验组患者术中疼痛程度明显减轻(P<0.05),手术并发症明显减少(P<0.05),术中及术后血氧饱和度降低(P<0.05),术前、术中、术后平均动脉压,术前、术中、术后心率,术前血氧饱和度、术中出血量、手术时间差异无统计学意义(P>0.05)。结论盐酸羟考酮注射液用于取环手术镇痛效果确切,且能够减少手术并发症,是一种安全有效的取环手术镇痛药物。

关键词: 盐酸羟考酮注射液取环手术镇痛安全

DOI：10.16118/j.1008-0392.2016.05.018

投稿时间：2016-03-22

基金项目:

Analgesic effect and safety of oxycodone hydrochloride injection in extraction of intrauterine device

JIN Xia,LIANG Jun-hua,GAO Hao,WANG Jian-jun,GAO Tian

(Dept. of Obstetrics and Gynecology, Tongji Hospital, Tongji University, Shanghai 200065, China)

Abstract:

Objective To assess the analgesic effect and safety of oxycodone hydrochloride injection in extraction of intrauterine device. Methods Seventy four women who underwent extraction of intrauterine device between July 2015 and October in our hospital were enrolled in the study. Patients were randomly assigned to receive intravenous injection of oxycodone hydrochloride 0.1mg/kg 5min(study group, n=37)or same volume of normal saline (control group, n=37)5min before operation. The general information, time of operation, intraoperative blood loss; and mean arterial pressure(MAP), pulse oxygen saturation (SpO₂), heart rate (HR) before, during and 5 minutes after operation were record. The analgesic effect was assessed by visual analogue scale (VAS). Results The VAS score of pain in study group was significantly lower than that in control group(P<0.05). Surgical complications in study group were less than those in control group (P<0.05). The SpO₂ during and 5min after operation in study group was lower than that in control group. There were no significant differences in time of operation, preoperative SpO₂, intraoperative blood loss; and MAP, HR before, during and 5 min after operation between study group and control group. Conclusion Oxycodone hydrochloride injection used during operation can reduce the pain of women undergoing extraction of intrauterine device with low incidence of surgical complications and less anxiety of patients.

Key words: oxycodone hydrochloride injection remove of intrauterine device analgesic effect safety