| 引用本文： |
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吴萍,李莹杰,罗斌.2型糖尿病合并高血压患者血清同型半胱氨酸的变化及意义[J].同济大学学报（医学版）,2015,36(6):99-102. [点击复制]
- WU Ping,LI Ying-jie,LUO Bin.Serum homocysteine level in type 2 diabetic patients complicated with hypertension[J].同济大学学报（医学版）,2015,36(6):99-102. [点击复制]
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| 摘要: |
| 目的 探讨2型糖尿病(T2DM)合并高血压患者血清同型半胱氨酸(Hcy)水平的变化及意义。方法 于2014年1月至2014年12月在同济大学附属同济医院内分泌科病房收集糖尿病住院患者527例,根据是否合并高血压分为单纯T2DM组和T2DM合并高血压组,调查所有患者的年龄、性别、文化程度、茶、咖啡、烟、酒、锻炼及糖尿病病程,用酶联免疫吸附法(ELISA)测定患者血清Hcy水平,并对两组指标分析比较。结果 单纯T2DM组与T2DM合并高血压组年龄、性别、文化程度、饮酒、糖尿病病程比较,差异有统计学意义(P<0.05)；单纯T2DM组血清Hcy水平(11.20±3.83μmol/L)低于T2DM合并高血压组Hcy水平(13.69±7.56μmol/L),差异有统计学意义(P<0.05)；患者Hcy水平与年龄、糖尿病病程呈明显正相关(r=0.232,P<0.001；r=0.112,P=0.010)。结论T2DM合并高血压患者血清Hcy水平明显增高,提示高Hcy水平与糖尿病患者血压升高有关,糖尿病患者年龄越大、糖尿病病程越长,Hcy水平越高,早期监测糖尿病患者的Hcy水平有利于对糖尿病患者的预后进行评估。 |
| 关键词: 2型糖尿病 高血压 同型半胱氨酸 |
| DOI：10.16118/j.1008-0392.2015.06.020 |
| 投稿时间：2015-02-06 |
| 基金项目: |
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| Serum homocysteine level in type 2 diabetic patients complicated with hypertension |
| WU Ping,LI Ying-jie,LUO Bin |
| (Dept. of Nutrition, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Objective To investigate serum homocysteine levels in type 2 diabetic (T2DM) patients complicated with hypertension and its clinical significance. Methods Five hundred and twenty seven patients with T2DM admitted in Department of Endocrinology, Tongji Hospital from January 2014 to December 2014, were enrolled in the study, including 356 cases complicated with hypertension and 171 cases without hypertension. Age, sex, education levels, tea and coffee consuming, smoking, alcohol drinking, exercise and duration of diabetes were investigated. The serum homocysteine levels were detected by ELISA method. The indicators of two groups were analyzed and compared. Result There were significant differences in age, sex, education level, alcohol drinking, duration of diabetes between T2DM group and T2DM with hypertension group(P<0.05). The serum homocysteine level in T2DM group was significant lower than that in T2DM with hypertension group(11.20±3.83μmol/L vs 13.69±7.56μmol/L, P<0.05). The serum homocysteine level was positively correlated with age and duration of diabetes(r=0.232,P<0.001；r=0.112,P=0.010). ConclusionT2DM patients complicated with hypertension have high serum homocysteine levels, suggesting that early monitoring blood pressure may help to evaluate the prognosis of diabetic patients. |
| Key words: type 2 diabetes hypertension homocysteine |
