ObjectiveTo investigate the expression of p16, p53, Ki-67 and the serum level of squamous cell carcinoma antigen SCC-Ag in cervical squamous cell carcinoma and its significance. Methods The tissue expression of p16, p53, Ki-67 was detected by immunohistochemistry, and serum SCC-Ag level was measured by chemiluinescent microparticle immunoassay in 31 cases of cervical squamous cell carcinoma and 31 cases of cervicitis. ResultsThe positive rates of p16, p53, Ki-67, SCC-Ag in cervicitis and cervical squamous cell carcinoma were 0%, 0%, 12.9%, 0% and 96.8%, 48.4%, 100%, 71%, respectively; tere were significant differences between two groups(P<0.05). The strong expression of p53 was correlated with lymph node or vasculature metastasis. The expression of Ki-67 was increased with raising of histologic grades. The serum SCC-Ag level was increased with increasing of FIGO stages(P<0.05). Spearman correlation analysis showed that p16 expression was positively correlated with serum SCC-Ag level in cervical squamous cell carcinoma(r=0.467,P<0.05); and the Spearman correlation coefficient was higher(r=0.59,P<0.05) in FIGO stage I. Conclusion p53, Ki-67 and serum SCC-Ag may be associated with the malignant degree and biological behavior of cervical squamous cell carcinoma.
