| 摘要: |
| 近年来,sigma-1受体在神经系统退行性疾病中已越来越受到关注,人们发现其具有介导细胞分化,神经元保护,促神经再生和延缓记忆减退等作用。本文基于一系列人类疾病动物模型及临床前研究,分析了sigma-1受体的特点及生物学效应,介绍了其在阿尔茨海默病(Alzheimer's disease, AD)发生发展过程中的作用及治疗方面的现状。Aβ对σ-1受体表达调节这一新视点,将成为研究AD发病机制的新方向。 |
| 关键词: sigma-1受体 阿尔茨海默病 β-淀粉样蛋白 |
| DOI：10.16118/j.1008-0392.2015.05.028 |
| 投稿时间：2015-02-12 |
| 基金项目:国家自然科学基金(81171163)；上海市教委重点课题资助项目(14ZZ044) |
|
| Progress of relationship between sigma-1 receptor and Alzheimer' disease |
| JIN Jia-li,LIU Xue-yuan |
| (Dept. of Neurology, Tenth People's Hospital,Tongji University, Shanghai 200072, China) |
| Abstract: |
| The role of sigma-1(σ-1) receptor in neurodegenerative disease has been drawn more and more attentions recently, it has been found that σ-1 receptor involves in cellular differentiation, neuroprotection, neuroplasticity and anti-amnesia of the brain. Based on animal models and preclinical studies of human diseases, this article describes the biological effects and treatment prospects of σ-1 receptor, and related cellular mechanisms of σ-1 receptor in pathogenesis of Alzheimer's disease, particularly the mechanisms of Aβ in σ-1 receptors expression, which would be a new direction for AD pathogenesis. |
| Key words: sigma-1 receptor Alzheimer's disease amyloid protein β |
