| 引用本文： |
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黄飞飞,蒋金法,孙冰,等.心肌梗死后心室重构与CD138+浆细胞的相关性研究[J].同济大学学报（医学版）,2015,36(5):85-89. [点击复制]
- HUANG Fei-fei,JIANG Jin-fa,SUN Bin,et al.Association of peripheral blood CD138+ plasmacytoid cells with ventricular remodeling after myocardial infarction[J].同济大学学报（医学版）,2015,36(5):85-89. [点击复制]
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| 摘要: |
| 目的 研究心肌梗死后心室重构与静脉血CD138+浆细胞的相关性。方法 选取急性前壁心肌梗死且急诊行PCI治疗的患者40例为心肌梗死组,另外选取健康者40例为对照组。使用流式细胞技术检测静脉血CD138+浆细胞数量,超声心动图测定左室舒张末期容积(left ventricle end-diastolic volume, LVEDV)。结果 急性期心肌梗死组患者静脉血CD138+浆细胞数量较对照组显著升高(P＜0.01),且第3天达到高峰。心肌梗死后非重构组的静脉血CD138+浆细胞数量较心肌梗死后重构组高(P＜0.01),但在1个月后均恢复基础水平。结论心肌梗死患者血CD138+浆细胞数量明显升高,但其数量与心肌梗死后心室重构呈负相关。 |
| 关键词: 心肌梗死 心室重构 CD138 浆细胞 |
| DOI：10.16118/j.1008-0392.2015.05.018 |
| 投稿时间：2015-04-22 |
| 基金项目:上海市科委引导项目(14411971600) |
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| Association of peripheral blood CD138+ plasmacytoid cells with ventricular remodeling after myocardial infarction |
| HUANG Fei-fei,JIANG Jin-fa,SUN Bin,SHEN Xiao-yun |
| (Dept.of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China;Dept.of Pharmacy, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Objective To investigate the association of peripheral blood CD138+ plasmacytoid cells with ventricular remodeling after myocardial infarction. Methods Forty patients with myocardial infarction and 40 healthy subjects(control group) were enrolled in the study. Flow cytometry was adopted to assay the amount of CD138+ plasmacytoid cells in venous blood. Left ventricle end-diastolic volume(LVEDV) of patients were measured by echocardiography. ResultsThe amount of CD138+ plasmacytoid cells in venous blood of patients was increased as compared to control group(P＜0.01), and reached the peak on the 3rd day. The amount of CD138+ plasmacytoid cells in patients with ventricular remodeling was higher than that in patients without ventricular remodeling, and returned to normal level after 1 month. Conclusion The increased amount of CD138+ plasmacytoid cells in patients with myocardial infarction may be related to ventricular remodeling. |
| Key words: myocardial infarction ventricular remodeling CD138 plasmacytoid cells |
