| 引用本文： |
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徐丽云,褚海青,李冰,等.18F-PET/CT在肺磨玻璃结节诊断中的应用[J].同济大学学报（医学版）,2015,36(5):61-65. [点击复制]
- XU Li-yun,CHU Hai-qing,LI Bing,et al.Clinical value of 18F-PET/CT for diagnosis of pulmonary ground-glass opacity nodules[J].同济大学学报（医学版）,2015,36(5):61-65. [点击复制]
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| 摘要: |
| 目的 探讨肺恶性磨玻璃结节(ground-glass opacity, GGO)的18F-FDG PET/CT影像学特点及18F-FDG PET/CT鉴别肺GGO良恶性的诊断价值。方法 对82例行PET/CT检查的肺GGO患者的临床资料及PET/CT影像学特点行回顾分析,其中51例患者均经手术病理确诊,31例随访疗效后明确诊断。结果 82例患者中,50例为恶性病变,32例为良性病变。单因素分析显示,PET/CT下GGO的密度类型、分叶、边界、毛刺、胸膜凹陷征、充气空泡征以及标准摄取值(standardized up take value, SUV)平均值、最大值对于良恶性鉴别有意义。多因素分析显示,混合型GGO、边界不清GGO及分叶GGO是恶性GGO的预测因子。ROC曲线分析结果显示SUV最大值与平均值对于GGO的良恶性鉴别准确性较低(AUC=0.679、0.682)。结论 18F-PET/CT对恶性GGO的诊断有良好的敏感性和特异性。 |
| 关键词: 磨玻璃结节 肺 18F-FDG PET/CT |
| DOI：10.16118/j.1008-0392.2015.05.013 |
| 投稿时间：2015-03-04 |
| 基金项目:上海市科学技术委员会医学引导项目(14411962900)；上海市科学技术委员会自然基金(12ZR1426200) |
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| Clinical value of 18F-PET/CT for diagnosis of pulmonary ground-glass opacity nodules |
| XU Li-yun,CHU Hai-qing,LI Bing,SHEN Li,SUN Qiu-hong,ZHAO Lan |
| (Dept. of Respiratory Medicine, Pulmonary Hospital, Tongji University, Shanghai 200433, China) |
| Abstract: |
| Objective To evaluate the application of 18F-FDG PET/CT imaging in diagnosis and differential diagnosis of lung ground-glass opacity(GGO) nodules. Methods The clinical data and PET/CT images of 82 patients with lung ground-glass opacity nodules were retrospectively reviewed. Among 82 cases the diagnosis was confirmed by operation and pathology in 51 cases and confirmed during follow-up in 31 cases. ResultsAmong 82 patients, 50 cases were malignant and 32 were benign. Univariate analysis showed that there were significant differences in density type, divided leaves on GGO PET/CT, boundary, burr, pleural indentation, inflatable vacuole sign, the average SUV values of SUV, SUV maximum between benign and malignant lesions. Multivariate analysis showed that mixed GGO, unclear boundary and leaf GGO was a predictor of malignancy. ROC curve showed that the accuracy of maximum SUV value and average value was low in differentiating benign and malignant GGO nodules(AUC=0.679,0.682). Conclusion 18F-PET/CT is highly sensitive and specific in diagnosis of malignant lung ground-glass nodules. |
| Key words: ground-glass nodules lung 18F-FDG PET/CT |
