| 摘要: |
| 长春西汀(Vinpocetine)最初因其具有增加脑血流和保护神经的作用而被用于治疗缺血性卒中、认知障碍等脑血管相关疾病。近年来,实验研究发现了其在保护神经功能上的新机制,如激活IKK信号通路发挥抗炎作用,抑制新生内膜增生和病理性血管重塑,以及通过抑制Akt、NF-κB通路的活性而抑制动脉粥样硬化形成等。因此,长春西汀在神经系统疾病尤其是脑血管病的治疗中得到了进一步的推广,并取得了确切疗效。本研究针对近年来长春西汀在神经系统疾病中的作用机制及其应用方面的研究进展进行综述。 |
| 关键词: 长春西汀 神经系统疾病 脑血管病 药物治疗 |
| DOI：10.16118/j.1008-0392.2015.04.026 |
| 投稿时间：2014-10-10 |
| 基金项目:国家自然科学基金面上项目(81371212)；上海市科委重点资助项目(13411951102,11411950303) |
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| Progress of vinpocetine in treatment of neurological diseases |
| XIE Jun-chao,LIU Xue-yuan |
| (Dept. of Neurology, Tenth People's Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Initially, Vinpocetine is applied in treatment of cerebrovascular diseases like ischemic stroke and cognitive impairment, owning to its potential of increasing cerebral blood flow and protecting neuronal cells. In recent years, experimental researches have revealed several novel mechanisms for its neuroprotective effects. For instance, vinpocetine can inhibit inflammatory responses by activating IKK signaling pathway. It also attenuates neointimal hyperplasia and pathological vascular remodeling. Besides, vinocetine exerts an anti-atherogenic effect by inhibiting the activity of Akt and NF-κB signaling. Therefore, vinocetine has extended its application and shown its curative effects for neurological diseases especially cerebral vascular disorders. This article reviews the mechanisms and applications of vinpocetine in treatment of central nervous system diseases. |
| Key words: vinpocetine nervous system disease cerebrovascular disease medication |
