ZHAO Pu-qing,YANG Qin-tong,LI Li,et al.Effectiveness of TCM clearing method for patients with diabetic foot and microcirculation dysfunction[J].同济大学学报（医学版）,2015,36(4):96-100. [点击复制]
Effectiveness of TCM clearing method for patients with diabetic foot and microcirculation dysfunction
ZHAO Pu-qing,YANG Qin-tong,LI Li,DONG Bing-bing,SUN Li-xia,HONG Liu
(Dept.of Internal Medicine, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai 200082, China;Dept.of Traditional Chinese Surgery, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai 200082, China;Dept.of Internal Medicine, Shanghai Huangpu District Central Hospital, Shanghai 200002, China;Dept.of Pediatrics, North Hospital of Huashan Hospital Affiliated of Fudan University, Shanghai 201907, China;Dept.of Nursing, Shanghai Traditional Chinese Medicine Integrated Hospital, Shanghai 200082, China;The Center for Disease Prevention and Control, Huangpu District, Shanghai 200023, China)
Abstract:
ObjectiveTo investigate the effectiveness of TCM clearing method(Qingfa) in treatment of patients with diabetic foot and microcirculation dysfunction. MethodsTwo hundred patients with diabetic foot were randomly divided into combined traditional Chinese and Western medicine treatment group (group A, n=100) and Western medicine control group (group B,n=100). All patients received basic treatment, in addition, patients in group A received Chinese medicine Qingfa,which was made up of Andrographis Paniculata, Rhizoma Paridis, Sedum Sarmentosum Bunge, Radix Aconiti, Panax Notoginseng, Cinnamomum Cam Phora, while patients in group B received cilostazol 100mg q.d. Blood biochemical parameters, microalbuminuria (MA) and hemorheology were tested and compared before and after treatment in two groups. Results Three were no significant differences in age, weight, height, body mass index (BMI), systolic blood pressure, diastolic blood pressure, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), microalbuminuria (MA), whole blood viscosity at low shear, whole blood viscosity in cutting, whole blood viscosity in high shear, plasma viscosity, hematocrit, erythrocyte aggregation and fibrinogen before treatment between two groups (P＞0.05). There were significant differences in TC, TG, UA, FPG, MA, whole blood viscosity at low shear, in cutting and in high shear, plasma viscosity, hematocrit, erythrocyte aggregation and fibrinogen after treatment between two groups (P＜0.05); while there were no significant differences in HDL-C, LDL-C, BUN, Cr, UA, 2hPG between two groups (P＞0.05). According to diagnosis and therapy efficacy criteria of “loss gangrene”, the efficacy of diabetic foot was significant different between two groups (P＜0.01). Conclusion Chinese medicine Qingfa treatment can improve microcirculation and promote wound healing in patients with diabetic foot.
