| 引用本文： |
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张立娟,田冬梅,童平,等.分析老年2型糖尿病患者血清25-羟维生素D与糖代谢、尿蛋白及HsCRP之间的关系[J].同济大学学报（医学版）,2015,36(4):86-89. [点击复制]
- ZHANG Li-juan,TIAN Dong-mei,TONG Ping,et al.Associations of 25hydroxy vitamin D level with energy metabolism, albuminuriaand hsCRP level in elderly patients with type 2 diabetes mellitus[J].同济大学学报（医学版）,2015,36(4):86-89. [点击复制]
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| 摘要: |
| 目的 分析老年2型糖尿病患者血清25-羟维生素D与糖代谢、尿蛋白及HsCRP之间的关系。方法 随机选取临床资料完善的住院老年糖尿病患者118例,分为维生素D缺乏组[25(OH)D＜25nmol/L]和维生素D不足组[25(OH)D 25~74nmol/L]。测定其25-羟维生素D、糖脂代谢指标、肾功能、电解质、尿白蛋白肌酐比及hs-CRP,采用Person相关分析,比较25-羟维生素D与其他糖脂代谢指标、尿蛋白及HsCRP的相关性。并对维生素D缺乏组和不足组的糖脂代谢指标,尿蛋白及HsCRP行t检验。结果 老年糖尿病患者的血清25-羟维生素D与FPG、HbA1c、hsCRP、ACR呈负相关,与Fins、Ca呈正相关。与Bun,Cr,P,PTH,TC,TG,LDL,HDL无关。25-羟维生素D缺乏组的HbA1c、hsCRP、ACR明显高于25-羟维生素D不足组(P＜0.05),25-羟维生素D缺乏组的Fins、Ca明显低于25-羟维生素不足组,差异有统计学意义(P＜0.05)。但两组的血脂、肾功能、FBG、PTH等差异无统计学意义。结论 老年2型糖尿病患者的25-羟维生素D水平普遍低下,维生素D缺乏可影响糖代谢,并可能通过炎症因子hsCRP影响蛋白尿产生。 |
| 关键词: 2型糖尿病 25-羟维生素D 尿白蛋白肌酐比 超敏C反应蛋白 |
| DOI：10.16118/j.1008-0392.2015.04.017 |
| 投稿时间：2015-01-14 |
| 基金项目: |
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| Associations of 25hydroxy vitamin D level with energy metabolism, albuminuriaand hsCRP level in elderly patients with type 2 diabetes mellitus |
| ZHANG Li-juan,TIAN Dong-mei,TONG Ping,WANG Fang |
| (Dept. of Endocrinology, People's Hospital of Putuo District, Shanghai 200060, China) |
| Abstract: |
| Objective To evaluate association of serum 25-hydroxyvitamin D [25(OH)D] with energy metabolism, albuminuria and hsCRP level in elderly type 2 diabetes mellitus (T2DM) patients. MethodsOne hundred and eighteen elderly T2DM patients were enrolled in this study. Serum 25(OH)D was measured, 25(OH)D levels ＜25nmol/L was defined as deficient and 25-74nmol/L as insufficient. Fasting blood glucose (FBG), fasting insulin (Fins), total cholesterol (TC), triglyceride (TG), high-density lipoprotein(HDL-C), low-density lipoprotein(LDL-C),blood urea nitrogen(Bun),creatinine(Cr),calcium(Ca),phosphorus(P), urine albumin-creatinine ratio (ACR) and high sensitive C-reactive protein (hsCRP) were compared. Pearson correlation coefficient was used to assess the association of25(OH) D with variables mentioned above in both groups. T test were used to assess the difference between the deficient 25(OH) D group and the insufficient 25(OH) D group. Results Based on the 25(OH) D levels 62 patients (52.5%) were in 25(OH) D deficient group and 56 patients (47.5%) were in 25(OH) D insufficient group. Serum 25(OH) D was negatively correlated with FBG, HbA1c, ACR and hsCRP (P＜0.05), and was positively correlated with Fins and Ca (P＜0.05); there were no significance correlation of 25(OH) D with TG, TC, LDL-C, HDL-C, Bun, Cr and PTH. Serum HbA1c, hsCRP, ACR were significantly higher, while Fins and Ca were lower in 25(OH) D deficient group than that in 25(OH) D insufficient group (P＜0.05), but there was no significant difference in lipid profile and renal function between two groups. Conclusion Declined 25 (OH) D level is prevalent in elderly T2DM patients. The deficiency of 25(OH) D may affect energy metabolism, and may be also involved in progression of albuminuria through inflammatory factors hsCRP. |
| Key words: type 2 diabetes mellitus 25-hydroxy vitamin D urine albumin-creatinine ratio hsCRP |
