| 摘要: |
| 骨质疏松好发于中老年人特别是绝经后妇女,以骨量降低和骨组织微结构破坏为特征,导致骨脆性增加和易于骨折的一种严重的进行性骨代谢疾病。现在已经成为世界性的公共卫生问题。随着研究的深入,除了钙、维生素D以外的越来越多的营养物质在骨质疏松的预防和治疗的作用已经被研究。镁是人体含量第四的矿物质,其广泛参与组织细胞的生命活动,也是骨组织的重要组成成分。基础研究和流行病学调查发现镁缺乏是骨质疏松的危险因素之一,本研究针对补镁治疗对于骨质疏松的影响及其相关机制进行综述。 |
| 关键词: 骨质疏松 补镁治疗 镁钙平衡 |
| DOI：10.16118/j.1008-0392.2015.03.029 |
| 投稿时间：2014-12-09 |
| 基金项目:国家自然科学基金(81101344/HO604) |
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| Research progress on magnesium in prevention and treatment of osteoporosis |
| LAI Min,YANG Chun-xi |
| (Dept. of Orthopedics, Tenth People’s Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Osteoporosis is characterized by osteopenia and disruption of microarchitecture in osseous tissue. It is a severe progressive metabolic disease that will result in osteopsathyrosis or fracture. The disease mainly occurs in senile individuals, especially in postmenopausal women, and now it becomes a worldwide public health problem. More and more studies have shown that besides calcium and vitamin D, other nutrients may also be effective in prevention and treatment of osteoporosis. As one of the main minerals in human body, magnesium is involved in many important biological functions including formation of osseous tissues. Recent basic and epidemiological studies have revealed that lack of magnesium is one of the risk factors of osteoporosis. This article reviews the research progress on the effect and associated mechanism of magnesium supplementation for prevention and treatment of osteoporosis. |
| Key words: osteoporosis treatment by magnesium supplement balance of calcium and magnesium |
