| 引用本文： |
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蒋承智,赵守亮.Cav 1.2羧基末端水解片段在牙胚发育过程中的表达[J].同济大学学报（医学版）,2015,36(2):29-32. [点击复制]
- JIANG Cheng-zhi,ZHAO Shou-liang.Expression of distal carboxyl-terminal fragments of Cav 1.2 in rat tooth germ development[J].同济大学学报（医学版）,2015,36(2):29-32. [点击复制]
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| 摘要: |
| 目的 检测Cav 1.2羧基末端水解片段在SD大鼠下颌第一磨牙牙胚发育早期的表达,探讨其在牙胚发育过程中的作用。方法 制备大鼠磨牙牙胚各发育阶段标本(胚胎14.5、16.5、18.5d及出生后1d),采用免疫组织化学的方法分析Cav 1.2羧基末端水解片段在牙胚组织中的表达与分布。结果 Cav 1.2羧基末端水解片段在牙胚发育早期的不同发育阶段表达各异,P1钟状晚期在牙尖部位的成牙本质细胞呈强阳性表达,由牙尖部向根方阳性逐渐减弱。结论 Cav 1.2羧基末端水解片段在牙胚发育过程中呈时间-空间特异性表达,推测它可能与牙胚的发育及细胞的分化过程密切相关。 |
| 关键词: Cav 1.2羧基末端水解片段 牙胚发育 |
| DOI：10.16118/j.1008-0392.2015.02.007 |
| 投稿时间：2014-07-28 |
| 基金项目: |
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| Expression of distal carboxyl-terminal fragments of Cav 1.2 in rat tooth germ development |
| JIANG Cheng-zhi,ZHAO Shou-liang |
| (School of Stomatology, Tongji University, Shanghai 200072, China;Dept.of Conservative Dentistry, Stomatology Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Objective To investigate the expression of distal carboxyl-terminal fragments of Cav 1.2 during rat tooth germ development. Methods Samples were collected from SD rat at various time points (embryonic d14.5,6.5,8.5 and postnatal d1). Immunohistochemistry technique was used to detect the expression of distal C-terminal fragments of Cav 1.2. Results The expression of distal C-terminal fragments of Cav 1.2 varied at different stages of embryo. At postnatal d1, it gradually weakened from the tip of the tooth to the root in enameloblasts and odontoblasts. Conclusion The expression of distal C-terminal fragments of Cav 1.2 is in a temporal-spatial specific pattern, which may be closely related to the tooth germ development and cell differentiation process. |
| Key words: distal carboxyl-terminal fragments of Cav 1.2 tooth germ development |
