| 引用本文： |
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张西 综述,许青 审校.TS表达与MMR状态联合检测在结直肠癌预后中的研究进展[J].同济大学学报（医学版）,2015,36(1):129-132. [点击复制]
- ZHANG Xi,XU Qing.Combined detection of thymidylate synthase expression and mismatch repair status in colorectal cancer: implications for prognosis[J].同济大学学报（医学版）,2015,36(1):129-132. [点击复制]
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| 摘要: |
| 胸苷酸合成酶(thymidylate synthetase, TS)是5-Fu(5-fluorouraci)发挥抗代谢作用治疗胃肠道恶性肿瘤的重要作用靶点,TS mRNA及蛋白表达与5-FU类药物的敏感性和抗药性密切相关。DNA错配修复MMR蛋白缺乏可以引起微卫星不稳定(microsatellite instability,MSI)。MSI亚型与5-FU类药物的疗效及结直肠癌患者预后相关。目前,将TS表达或MMR状态单独作为结直肠癌预后因子仍存在争议,因此联合检测TS表达与MMR状态 来判断结直肠癌患者预后的研究受到越来越多的关注。 |
| 关键词: 胸苷酸合酶 错配修复 结直肠肿瘤 预后 |
| DOI：10.16118/j.1008-0392.2015.01.029 |
| 投稿时间：2014-03-25 |
| 基金项目:上海市科委科研计划(11411950602) |
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| Combined detection of thymidylate synthase expression and mismatch repair status in colorectal cancer: implications for prognosis |
| ZHANG Xi,XU Qing |
| (Dept. of Oncology, Tenth People's Hospital, Tongji University, Shanghai 200072, China) |
| Abstract: |
| Thymidylate synthase (TS) is an important target of 5-fluorouracil(5-FU)in anti-metabolic therapy of gastrointestinal malignancies. The expression of TS mRNA and TS protein are closely related to sensitivity of 5-FU-based chemotherapy. Microsatellite instability (MSI) can be caused by deficient DNA mismatch repair(MMR). MSI was reported to be associated with the efficacy of 5-Fu-based chemotherapy and prognosis of patients. It is questionable whether a single marker of TS or MMR might play a relevant prognostic and predictive role because colorectal cancer is a complex and heterogeneous disease. Combined analysis of MMR status and TS expression may add valuable information to the prognosis of colorectal cancer patients. |
| Key words: thymidylate synthase mismatch repair colorectal cancer prognosis |
