Clinical application of dexmedetomidine combined with LMA supreme general anesthesia in elderly patients undergoing radical mastectomy
HUANG Yong12,YU bin1,WU Lei2,LUO Wen-jie1
(Dept. of Analgesia, Tongji Hospital, Tongji University, Shanghai 200065, China; 2. Dept. of Anesthesiology, People＇s Hospital of Putuo District, Shanghai 200060, China)
Abstract:
Objective To evaluate the clinical efficacy and safety of dexmedetomidine combined with LMA Supreme general anesthesia in elderly patients undergoing radical mastectomy.Methods Sixty patients aged 65-75 years,ASA grade Ⅰ-Ⅱ undergoing elective radical mastectomy were randomly allocated in LMA Supreme group（Group S） and dexmedetomidine combined with LMA Supreme（Group D） with 30 cases each.The SBP,DBP,HR were recorded before anesthesia induction（T0）,after induction（T1） immediately after inserting LMA（T2）,on skin incision（T3）,immediately after removing LMA（T4）.The dosage of general anesthetics,the time of revival and extubation were calculated.Intraoperative regurgitation and pulmonary microaspiration,agitation bucking and ague at awakening,postoperative hoarseness and pharyngodynia were documented.VAS was evaluated after1,2 and 6 hours of operation.Results Compared with the baseline value at T0,the SBP,DBP,HR in group S were significantly decreased at T1（P〈0. 05） and significantly increased at T3（P〈0. 05）.The HR was significantly decreased at T1,T2,T3 in group D（P〈0. 05）.Compared with group D,the SBP and DBP in group S were significantly lower at T1（P〈0. 05）;and the SBP,DBP,HR were higher at T3（P〈0. 05）.No intraoperative regurgitation and pulmonary microaspiration and postoperative hoarseness were found in both groups.Compared with group S,the dosage of general anesthetics and the time of revival and extubation in group D were significantly shortened and the agitation bucking ague at awakening and postoperative pharyngodynia were significantly decreased（P〈0. 05）.The VAS in group D at 1,2 hours after operation was lower than that in group S（P〈0. 05）.Conclusion Dexmedetomidine combined with LMA Supreme general anesthesia has a satisfactory and safe effect with better hemodynamic stability,less consumption of anesthetics and faster consciousness recovery in elderly patients undergoing radical mastectomy.
