| 引用本文： |
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柳先丽,舒晓亮,徐涵,等.co-3多不饱和脂肪酸对疾病炎症 反应影响的Meta分析[J].同济大学学报（医学版）,2014,35(6):17-22. [点击复制]
- LIU Xian-li,SHU Xiao-liangx,XU Han,et al.Effects of w-3 polyunsaturated fatty acids on inflammation ： a meta-analysis[J].同济大学学报（医学版）,2014,35(6):17-22. [点击复制]
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| 摘要: |
| 目的 系统评价w-3多不饱和脂肪酸对疾病炎症反应的影响。方法计算机检索PubMed、Web of Science、 EMbase、CBM、中国学术期刊全文数据库(CNKI)、万方中文期刊全文数据库等数据库,检索时限从建库到2013年10 月，纳入所有co-3多不饱和脂肪酸对疾病炎症反应影响的随机对照试验,按照纳入排除标准选择文献、提取资料和进 行质量评价后，采用RevMan 5. 2软件进行Meta分析。结果共纳入12个随机对照试验,合计600例患者。Meta分 析结果显示：与对照组相比,<0-3多不饱和脂肪酸可降低患者的C反应蛋白（CRP)[M)= -13.06；95% CI( -24.79， -1.33),P=0.03]、白细胞介素（IL"6)[MD= -42.99；95% Cl ( -62. 09, - 16. 97),尸=0.001]、肿瘤坏死因子（TNF-a)[MD= -23.15；95% C7(-36.30，-1.00),尸=0.0006]水平，对白蛋白变化未见明显差异。结论co-3多不饱和 脂肪酸可降低患者C反应蛋白（CRP)、白细胞介素（IL4)、肿瘤坏死因子（TNF-oO水平，能够有效减轻多种疾病患者 术后或治疗后过度的炎性反应，改善患者治疗后营养状态和免疫功能,促进机体康复。 |
| 关键词: c0-3多不饱和脂肪酸 炎性细胞因子 炎症反应 Meta分析 |
| DOI：10.3969/j. issnl008 -0392.2014.06.004 |
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| 基金项目:国家“十二五”科技支撑计划课题(2012BAI35B03) |
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| Effects of w-3 polyunsaturated fatty acids on inflammation ： a meta-analysis |
| LIU Xian-li,SHU Xiao-liangx,XU Han,ZHAO Jian |
| (Dept. of Nutrition, East Hospital, Tongji University, Shanghai 200120, China;Dept. of Nutrition, Tongji Hospital, Tongji University, Shanghai 200065, China) |
| Abstract: |
| Objective To systematically evaluate the effect of omega-three (to-3) polyunsaturated fatty acids on inflammatory response. Methods Literature was retrieved by conputer from electronic databases including PubMed ’ Web of Science，EMbase，CBM，China National Knowledge Infrastructure (CNKI)， Wanfang database since data establishment to October 2013. Randomized clinical trials (RCTs) were included according to the inclusive and exclusive criteria and the quality was assessed. Meta analysis was conducted with Revman 5.1 software. Results Twelve RCTs involving 600 patients were included. Metaanalysis showed that con^ared with the control group, o>-3 polyunsaturated fatty acids reduced C-reactive protein (CRP) [MD = - 13.06； 95% Cl ( —24 79，- 1. 33),P =0.03], interleukin-6 (IL-6) [MD = -42.99；95% Cl ( -62.09, -16.97)，尸=0.001], tumor necrosis factor (TNF-a) [MD = -23.15；95% Cl(-36.30, - 1.00)，尸=0.000 6], but not albumin levels. Conclusion Omega-3 polyunsaturated fatty acids can reduce the levels of inflammation-related factors CRP, IL-6 and TNF-a. |
| Key words: omega-3 polyunsaturated fatty acids inflammatory cytokines inflammation metaanalysis |
