摘要: |
目的探讨肥胖者血清成纤维细胞生长因子21(fibroblast growth factor 21,FGF21)水平及其临床意义。方法选取50例肥胖患者(BMI≥28 kg/m2)为试验组,同期行健康体检正常的志愿者(BMI〈24 kg/m2)50例为对照组。记录受试者的身高、体质量、血压、腰围、臀围,计算腰臀比、体质量指数,检测血脂、超敏C反应蛋白、空腹血糖、胰岛素、糖化血红蛋白等指标,并采用酶联免疫吸附法检测血清FGF21的表达。结果肥胖组FGF-21的水平明显高于对照组,差异有统计学意义(P〈0.05);FGF21与腰围、腰臀比(waist-to-hip ratio,WHR)、空腹血浆葡萄糖(fasting plasma glucose,FPG)、HbA1c、空腹血清胰岛素(fasting insulin,FINS)、三酰甘油(TG)、超敏C反应蛋白(hsCRP)呈正相关,与高密度脂蛋白胆固醇(HDL-C)呈负相关(P〈0.05);多元线性回归结果显示,肥胖、血糖升高和三酰甘油升高是FGF21表达增加的独立危险因素。结论FGF21有可能成为代谢综合征的预测因子。 |
关键词: 成纤维细胞生长因子21 肥胖 2型糖尿病 代谢综合征 |
DOI:10.3969/j.issn1008-0392.2014.04.021 |
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基金项目: |
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Serum FGF21 levels in obese subjects and its clinical significance |
ZHU Bei,JIANG Yi-lan |
(Dept. of Endocrinology, Rugao People's Hospital, Nantong 226500, Jiangsu Province, China) |
Abstract: |
Objective To investigate serum fibroblast growth factor 21 (FGF-21) levels in obese subjects and its clinical significance. Methods Fifty obese subjects (BMI ≥28 kg/m2) and fifty normal controls(BMI 〈 24 kg/m2) were recruited. Fasting serum FGF-21 levels were measured with enzyme-linked immunosorbent assay. The anthropometric parameters, glucose, lipids, insulin and high sensitive C-reactive protein (hs-CRP) levels were also measured. Results Serum FGF-21 levels were significantly higher in obese subjects than those in controls (P〈0.05 ). Fasting serum FGF-21 was positively correlated with waist circumference, waist-to-hip ratio (WHR), fasting plasma glucose ( FPG), HbAlc, fasting insulin (FINS), triglyceride (TG) and hs-CRP; negatively correlated with high-density lipoprotein in cholesterol (HDL-C). Multivariate linear regression analysis showed that increased waist circumference, elevated FPG and triglycerides were independent risk factors for increased serum FGF-21. Conclusion Serum FGF-21 level may be of value in prediction of metabolic syndrome. |
Key words: fibroblast growth factor 21 obesity type 2 diabetes meUitus metabolic syndrome |