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徐昕,张春阳,李冰洁.2型糖尿病患者肾小球滤过率及其影响因素研究[J].同济大学学报（医学版）,2014,35(3):110-113. [点击复制]
XU Xin,ZHANG Chun-yang,LI Bing-jie.Glomerular filtration rate and its effecting factors in type 2 diabetes[J].同济大学学报（医学版）,2014,35(3):110-113. [点击复制]

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2型糖尿病患者肾小球滤过率及其影响因素研究
徐昕¹,张春阳²,李冰洁¹
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(1.同济大学附属同济医院住院医师规范化培训科,上海200065;2.同济大学附属同济医院内分泌科,上海200065)

摘要:

目的分析2型糖尿病患者肾小球滤过率（Glomerular Filtration Rate,GFR）的影响因素。方法以^99m锝（Tc）-二乙三胺（DTPA）肾动态显像测定GFR的310例2型糖尿病患者为研究对象,探讨糖尿病患者GFR的影响因素。结果高血压组的GFR比血压正常组明显下降;GFR与年龄、糖尿病病程、体质量指数、收缩压、尿素氮、血肌酐、尿微量白蛋白、尿β2-微球蛋白呈负相关;与空腹血糖、糖化血红蛋白呈正相关;年龄、体质量指数、血肌酐是影响2型糖尿病患者GFR的独立相关因素。结论体质量、血压、血糖、尿白蛋白是糖尿病肾病的危险因素,积极控制可以减少和延缓糖尿病肾病的发生和发展。

关键词: 2型糖尿病糖尿病肾病肾小球滤过率

DOI：10.3969/j.issnl008-0392.2014.03.026

基金项目:

Glomerular filtration rate and its effecting factors in type 2 diabetes

XU Xin¹,ZHANG Chun-yang²,LI Bing-jie¹

(1.Section for Residency Training, Tingyi Hospital, Tingji University, Shanghai 200065, China;2. Dept. of Endocrinology, Tingji Hospital, Tingji University, Shanghai 200065, China)

Abstract:

Objective To determine the glomerular filtration rate（GFR） and effecting factors in patients with type 2 diabetes.Methods The GFR of 310 patients with type 2 diabetes was evaluated by^99mT_C-DTPA dynamic renal imaging method,and the effecting factors of GFR was analyzed.Results The GFR was negatively correlated with age,course of diabetes,body mass index（BMI）,systolic pressure（SBP）,blood rrea nitrogen（BUN）,serum creatinine（Scr）,urinary albumin（MAU）,Beta-2-microglobulin（β?-MG）,and positively correlated with fasting blood-glucose（FBG）,glycosylated hemoglobin（HbA1C）.Multivariate regression analysis showed that Scr,BMI and age were independent effective factors for GFR in type 2 diabetes.Conclusion Body weight,blood pressure,FBG and urinary albumin are risk factors of diabetic nephropathy in patients with type 2 diabetes.

Key words: type 2 diabetes diabetic nephropathy glomerular filtration rate