| 引用本文： |
-
赵泽明,Thomas Becker,范跃祖,等.肝细胞肝癌肝移植的预后因素分析[J].同济大学学报（医学版）,2014,35(1):52-57. [点击复制]
- ZHAO Ze-ming,Thomas Becker,FAN Yue-zu,et al.Prognostic factors of liver transplantation for hepatocellular carcinoma[J].同济大学学报（医学版）,2014,35(1):52-57. [点击复制]
|
|
| 本文已被：浏览 393次 下载 311次 |
码上扫一扫！ |
| 肝细胞肝癌肝移植的预后因素分析 |
| 赵泽明1,ThomasBecker2，3,范跃祖1,BastianRinge2,JurgenKlempnauer2 |
|
|
| (1.同济大学附属同济医院普外科，上海 200065,中国;2.汉诺威医科大学内脏移植外科，汉诺威30625，德国;
3.基尔大学医院内脏移植外科，基尔24105，德国
3.基尔大学医院内脏移植外科，基尔24105，德国;1.同济大学附属同济医院普外科，上海20006,中国;
3.基尔大学医院内脏移植外科，基尔24105，德国）) |
|
| 摘要: |
| 目的评价肝细胞肝癌（hepatocellularcarcinoma, HCC)原位肝移植后的领后相关因素。方法回顾性分 析1993年11月到2006年5月期间汉诺威医科大学对117例HCC进行肝移植的经验。结果经多因素分析，肿瘤大小和肿瘤数量（米兰标准或加州标准）、微血管侵犯、移植前治疗和肿瘤复发是影响患者生存预后的重要因素。结论原位肝移植是治疗HCC的理性术式;合适的选择标准，积极的移植前治疗，复发的有效控制，是患者获得良好预后的关键。 |
| 关键词: 肝细胞肝肿瘤 肝移植 预后 |
| DOI：10.3969/j.issnl008-0392.2014.01.011 |
|
| 基金项目:国家自然科学基金（81072004) |
|
| Prognostic factors of liver transplantation for hepatocellular carcinoma |
| ZHAO Ze-ming1,Thomas Becker2，3,FAN Yue-zu1,Bastian Ringe2,Jurgen Klempnauer2 |
| (1. Dept. of General Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China;2. Dept. of Abdominal and Transplantation Surgery, Medical School of Hanover, Carl-Neuberg Strl, Hanover 30625, Germany; 3. Dept, of Abdominal and Transplantation Surgery, Kiel University School of Medicine, Kiel 24105，Germany) |
| Abstract: |
| Objective To evaluate the results of liver transplantation (LT) for hepatocellular carcinoma (HCC), and to identify major factors influencing the patients’ outcome. Metiiods One hundred and seventeen cases of LT for HCC were retrospectively analyzed in a single transplantation center, Medical School of Hanover, during the period between November 1993 and May 2006. The cumulative survival rates were calculated using the Kaplan-Meier method and the differences between various groups were analyzed by Log-rank test. Results The tumor size and number are two major factors affecting prognosis of LT for HCC. Analysis of multiple variables on overall survival showed that tumor size and number (Milan criteria and UCSF criteria)，presence of micro-vascular invasion, with or without preoperational treatment and tumor recurrence were statistically significant predictors of survival. Conclusion LT is a rational therapeutic option for patients with HCC. Suitable selection criteria, positive pre-transplantation treatment and recurrence effective control are crucial for obtaining a good prognosis. |
| Key words: hepatocellular carcinoma liver transplantation prognosis. |