| 摘要: |
| 目的通过检测急性心肌梗死患者的炎症因子(hs-CRP、IL-6、TNF-α)的水平,观察高血压病及血压水平对急性心肌梗死患者炎症反应的影响。方法收集诊断为急性心肌梗死且发病24 h以内的患者110例,根据既往是否有高血压病史将患者分为高血压病组(51例)和非高血压病组(59例),再根据入院24 h以内血压水平是否升高将患者分为血压正常组(70例)和血压升高组(40例),分别测定患者血清中hs-CRP、IL-6、TNF-α的水平。结果高血压病组患者的hs-CRP、IL-6、TNF-α水平显著高于非高血压病组(P=0.008、P=0.008、P=0.027);与血压正常组比较,血压升高组患者的hs-CRP、IL-6、TNF-α水平差异无统计学意义(P=0.524、P=0.822、P=0.781)。结论在急性心肌梗死患者中炎症反应与高血压病关系密切,但与入院时的血压水平关系不大。高血压病可能通过扩大炎症反应而影响急性心肌梗死的发生发展。 |
| 关键词: 高血压病 急性心肌梗死 炎症因子 |
| DOI：10.3969/j.issn1008 -0392.2012.05.020 |
| 投稿时间：2011-10-10 |
| 基金项目: |
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| Effects of primary hypertension and blood pressure on inflammatory factors in patients with acute myocardial infarction |
| L Jin-hui |
| (Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China) |
| Abstract: |
| Objective To investigate the impact of primary hypertension and blood pressure on inflammatory factors (hs-CRP, IL-6, TNF-a) in patients with acute myocardial infarction (AMI). Methods one hundred and ten patients were admitted within 24 h of AMI onset, including 51 patients with primary hypertension and 59 patients without primary hypertension. According to blood pressure at hospital admission patients were grouped as normotensive group (n =70) and hypertensive group (n = 40) . Plasma level of hs-CRP, IL-6 and TNF-a were determined at admission using ELISA method. Results Plasma levels of hs-CRP (P =0. 008) , IL-6 (P = 0. 008) and TNF-a (P =0. 027) were significant increased in patients with primary hypertension compared to those in patients without primary hypertension. There were no statistically significant differences in plasma level of hs-CRP (P =0. 524), IL-6(P = 0. 822) and TNF-a (P = 0. 781) between hypertensive group and normotensive group. Conclusion Inflammatory response has significant correlation with primary hypertension, but not the blood pressure at hospital admission in AMI patients, indicating that primary hypertension may affect the development of acute myocardial infarction by exaggerating the inflammatory reaction. |
| Key words: primary hypertension acute myocardial infarction inflammatory factors |
