Objective To evaluate the efficacy and safety of linezolid,vancomycin hydrochloride and teicoplanin in elderly patients with lower respiratory tract Gram-positive bacterial infection.Methods The clinical data of 55 elderly patients with lower respiratory tract Gram-positive bacterial infection were retrospectively analyzed.Patients were treated with linezolid(600mg,linezolid,7-14d,n=11),norvancomycin hydrochloride(400mg,3 times everyday,7-14d,n=18) or teicoplanin(first dose,400mg,maintenance dose 200mg,7-14d,n=26).The clinical effect,adverse effect and median length of hospital stay of each group were analyzed.Results The clinical effective rates of linezolid,norvancomycin hydrochloride and teicoplanin groups were 81.8%(9/11),55.6%(10/18)and 61.5%(16/26),respectively(P=0.345>0.05).The bacterial clearance rates of three groups were 81.8%(9/11),72.5%(13/18) and 77.4%(20/26),respectively(P=0.837>0.05).The median length of hospital stay of three groups were(26.3±3.05),(32.8±4.11) and(33.5±3.55)d;that of linezolid group was significantly shorter than those of other 2 groups.There were no obvious adverse effects detected in three groups.Conclusion Linezolid,norvancomycin hydrochloride,teicoplanin are all safe and effective antibiotics for elderly patients with lower respiratory tract Gram-positive bacterial infection.
