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潘菊萍,杨晓峰,邓兵.动态动脉硬化指数和高血压患者早期肾功能损害的相关性观察[J].同济大学学报（医学版）,2011,32(5):86-89. [点击复制]
PAN Ju-ping,YANG Xiao-feng,DENG Bing.Association of ambulatory arterial stiffness index with early renal dysfunction in hypertensive patients[J].同济大学学报（医学版）,2011,32(5):86-89. [点击复制]

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动态动脉硬化指数和高血压患者早期肾功能损害的相关性观察
潘菊萍¹,杨晓峰¹,邓兵²
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(1. 同济大学附属同济医院急诊内科,上海200065;2. 同济大学附属同济医院心内科,上海200065)

摘要:

目的探索动态动脉硬化指数（ambulatory arterial stiffness index,AASI）对高血压患者早期肾功能损害的评价作用。方法以AASI≥0.55作为异常升高的临界值,将患者分为两组。两组患者性别构成、年龄、体质量、空腹血糖、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、肌酐、心率均无统计学显著差异。以AASI为自变量,eGFR为因变量行Pearson相关分析。结果 eGFR与AASI呈显著负相关（Pearson积差相关系数-0.312,P值0.000）。结论动态动脉硬化指数与早期肾功能减退相关。

关键词: 动脉硬化指数高血压肾功能损伤

DOI：10.3969/j.issn1008-0392.2011.05.020

基金项目:

Association of ambulatory arterial stiffness index with early renal dysfunction in hypertensive patients

PAN Ju-ping¹,YANG Xiao-feng¹,DENG Bing²

(1.Dept.of Emergency,Tongji Hospital,Tongji University,Shanghai 200065,China;2.Dept.of Cardiology,Tongji Hospital,Tongji University,Shanghai 200065,China)

Abstract:

Objective To investigate the association of ambulatory arterial stiffness index(AASI) with renal dysfunction in hypertensive patients.Methods AASI≥0.55 was taken as cut-off value,the patients were divided into two groups.There were no statistical significance in gender,age,body weight,fasting glucose,total cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol, triglycerides,serum creatinine and heart rate between two groups.Taking AASI as the independent variable,eGFR as the dependent variable,Pearson correlation analysis was made.Results There was significant negative correlation of AASI with eGFR(r=-0.312,P=0.000).Conclusion Ambulatory arterial stiffness index is associated with early renal dysfunction.

Key words: ambulatory arterial stiffness index hypertension renal dysfunction