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韩巍巍,Schaffrath M,Holze V,等.抗苗勒激素对ICSI治疗中卵巢反应的预测价值[J].同济大学学报（医学版）,2011,32(1):40-45. [点击复制]
HAN Wei-wei,Schaffrath M,Holze V,et al.Value of anti-Müllerian hormone on predicting ovarian response during intracytoplasmic sperm injection cycles[J].同济大学学报（医学版）,2011,32(1):40-45. [点击复制]

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抗苗勒激素对ICSI治疗中卵巢反应的预测价值
韩巍巍^1,2,SchaffrathM²,HolzeV²,PollowK²,SeufertR²,童晓文¹
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(1. 同济大学附属同济医院妇保中心,上海 200065;2. 德国美因茨大学医院妇产科生殖中心,德国美因茨 55101)

摘要:

目的探讨接受卵胞浆内单精子注射（intracytoplasmic sperm injection,ICSI）治疗患者血清及卵泡液中AMH水平对卵巢反应性的预测价值。方法 53例接受ICSI治疗的患者分别使用促性腺激素释放激素激动剂（GnRH-a,40例）长方案和促性腺激素释放激素拮抗剂（GnRH拮抗剂,13例）联合方案促排卵。接受GnRH-a长方案治疗患者降调节后促性腺激素使用第2天检测血清AMH水平。53例患者卵泡穿刺（oocyte pick-up,OPU）当天检测血清及卵泡液中AMH水平。应用SPSS10.0软件分析血清及卵泡液中AMH水平与卵巢反应的相关性。结果 GnRH-a长方案组和GnRH-拮抗剂联合方案组,OPU当天血清及卵泡液中AMH水平差异无统计学意义。GnRH-a长方案促性腺激素治疗第2天血清AMH水平,两组OPU当天血清及卵泡液中AMH水平与获卵数、成熟卵数成正相关,与患者年龄、促性腺激素使用剂量呈负相关,与受精率没有明显相关性。结论控制性超排卵治疗周期血清及卵泡液中AMH水平能预测ICSI治疗后的卵巢反应性。

关键词: 抗苗勒激素卵巢反应性卵胞浆内单精子注射

DOI：10.3969/j.issn1008-0392.2011.01.040

基金项目:

Value of anti-Müllerian hormone on predicting ovarian response during intracytoplasmic sperm injection cycles

HAN Wei-wei^1,2,Schaffrath M²,Holze V²,Pollow K²,Seufert R²,TONG Xiao-wen¹

(1.Dept.of Obstetrics and Gynecology,Tongji Hospital,Tongji University,Shanghai200065,China;2.Dept.of Reproductive Center,Obstetrics and Gynecology,University of Mainz,Mainz 55101,Germany)

Abstract:

Objective To study the effect of anti-Müllerian hormone(AMH) in serum and follicular fluid(FF) on predicting ovarian response during intracytoplasmic sperm injection(ICSI) cycles.Methods GnRH agonist long-protocol and GnRH antagonist multiple-dose flexible-protocol were performed in a total of 53 patients undergoing ICSI procedure.Serum AMH was determined on the second day of GnRH agonist protocol(40 patients) under the down-regulation effect and no hormone measurement was performed at the initial stage of GnRH antagonist protocol.AMH concentrations in serum and FF were measured on the oocyte pick-up(OPU) day of both stimulation protocols(53 patients).The correlations between AMH values and ovarian response were analyzed statistically(SPSS 10.0).Results AMH concentrations in serum and FF on OPU day were similar between two stimulation groups.Serum AMH values obtained on the second day of GnRH agonist protocol,and AMH concentrations in serum and FF on OPU day of two stimulation protocols correlated positively with retrieved oocytes account(total and MⅡoocytes).Serum and FF AMH levels were observed to have negative correlations with the maternal age and the total gonadotropin administration dose.No statistically significant correlation was found between AMH levels and fertilization rate(FR).Conclusion AMH concentrations in serum and FF during controlled ovarian hyperstimulation could predict ovarian response in patients undergoing ICSI procedure.

Key words: anti-Müllerian hormone ovarian response ICSI