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刘远飞,,,,,,陈莹,程静,等.多通道阻抗联合24 h食管pH监测在胃食管反流病中的应用[J].同济大学学报（医学版）,2010,31(6):51-54. [点击复制]
- LIU Yuan-fei,CHEN Ying,CHENG Jing,et al.Application of combined multichannel intraluminal impedance and 24 h esophageal pH monitoring in the diagnosis of gastroesophageal reflux disease[J].同济大学学报（医学版）,2010,31(6):51-54. [点击复制]
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| 多通道阻抗联合24 h食管pH监测在胃食管反流病中的应用 |
| 刘远飞1,,,,,,陈莹1,程静1,王琛2,朱立人3,许树长1 |
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| 摘要: |
| 目的探讨多通道阻抗联合24 h pH监测在胃食管反流病（gastroesophageal reflux disease,GERD）,尤其在pH（-）GERD患者中的应用价值。方法 48例GERD患者应用多通道阻抗联合24 h pH监测,根据Demeester评分分为pH（-）与pH（＋）,其中pH（-）GERD 30例,pH（＋）GERD 18例;另相同监测健康大学生志愿者20例做正常对照组。结果 GERD组酸反流次数、卧位食团暴露时间及总食团暴露时间均高于正常对照组,差别有统计学意义（P=0.01,P=0.002,P=0.03）;GERD组非酸反流次数低于正常对照组,差别有统计学意义（P=0.002）。pH（-）GERD组卧位食团暴露时间高于正常对照组（P=0.015）,pH（-）GERD酸反流次数及卧位食团暴露时间均低于pH（＋）GERD,差别有统计学意义（P=0.02,P=0.04）。结论多通道阻抗联合24 h pH监测能发现更多的反流事件,在GERD尤其对pH（-）GERD患者的诊断有实用意义,需进一步研究。 |
| 关键词: 多通道阻抗监测 pH 24 h监测 胃食管反流病 Demeester评分 |
| DOI：10. 3969/j. issnl008 - 0392.2010.06.012 |
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| 基金项目:上海市科委临床重点资助项目（054119544) |
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| Application of combined multichannel intraluminal impedance and 24 h esophageal pH monitoring in the diagnosis of gastroesophageal reflux disease |
| LIU Yuan-fei1,CHEN Ying1,CHENG Jing1,WANG Cheng2,ZHU Li-ren3,XU Shu-chang1 |
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| Abstract: |
| Objective To investigate the application of combined multichannel intraluminal impedance （MII） and 24 h esophageal pH monitoring in gastroesophageal reflux disease（GERD）,especially in pH （- ）GERD patients.Methods Forty-eight patients underwent combined MII and 24 h pH monitoring, and patients were divided into pH（- ） GERD and pH（＋ ） GERD group according to Demeester score. The normal values of 20 healthy volunteers who underwent MII and 24 h pH monitoring were served as controls.Results The acid reflux frequency,ambulatory alimentary bolus exposure time and total alimentary bolus exposure of GERD were relatively higher than those in control group respectively（P = 0.01,P =0.002,P =0.03）,the non-acid reflux frequency in GERD group were relatively lower than those in control group（P =0.002）.The ambulatory alimentary bolus exposure time of pH（- ）GERD were relatively higher than that in normal group（P =0.015）,the weak base reflux frequency of pH（- ） GERD were relatively lower than that in control group（P =0.022）.The non-acid reflux frequency and ambulatory alimentary bolus exposure time of pH（- ） GERD were relatively higher than those in pH（＋） GERD（P=0.02,P=0.04）.Conclusion Combined multichannel intraluminal impedance and 24 h esophageal pH monitoring is helpful in the diagnosis of gastroesophageal reflux disease,especially in the pH（- ） GERD patients. |
| Key words: multichannel intraluminal impedance 24 h esophageal pH monitoring gastroesophageal reflux disease Demeester scores |