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张轶,陈昶,丁嘉安,等.新辅助化疗对Ⅲ期非小细胞肺癌纵隔转移淋巴结的降期作用[J].同济大学学报（医学版）,2010,31(3):84-87. [点击复制]
ZHANG Yi,CHEN Chang,DING Jia-an,et al.Down-staging effect of neoadjuvant chemotherapy on mediastinal lymph nodes in patients with stage Ⅲ non-small cell lung cancer[J].同济大学学报（医学版）,2010,31(3):84-87. [点击复制]

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新辅助化疗对Ⅲ期非小细胞肺癌纵隔转移淋巴结的降期作用
张轶^1,2,陈昶¹,丁嘉安¹,姜格宁¹,高文¹,徐志飞²
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摘要:

目的探讨新辅助化疗对Ⅲ期非小细胞肺癌（non-small cell lungcancer，NSCLC）的纵隔转移淋巴结（mediastinal lymph nodes metastasis，N2）的降期作用。方法回顾性分析接受新辅助化疗的43例患者的临床资料。结果N2降期患者的预后较好，而N2是否融合对于降期与否有显著影响，患者的性别、年龄、肿瘤的病理类型、化疗一手术间隔时间和化疗方案与N2降期与否均无关。结论新辅助化疗能够显著改善Ⅲ期NSCLC的手术治疗效果，而单个、孤立的N2患者有可能获得更好的降期疗效，进而获得较好的预后。

关键词: 非小细胞肺肿瘤新辅助化疗纵隔淋巴结

DOI：10.3969/j. i s sn1008 - 0392.2010.03.02 1

投稿时间：2010-04-06

基金项目:

Down-staging effect of neoadjuvant chemotherapy on mediastinal lymph nodes in patients with stage Ⅲ non-small cell lung cancer

ZHANG Yi^1,2,CHEN Chang¹,DING Jia-an¹,JIANG Ge-ning¹,GAO Wen¹,XU Zhi-fei²

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Abstract:

Objective To study the down-staging effect of neoadjuvant chemotherapy on mediastinal （N2） lymph nodes in patients with stage Ⅲ non-small cell lung cancer （NSCLC）. Methods Clinical data of 43 stage Ⅲ NSCLC patients with neoadjuvant chemotherapy were reviewed retrospectively. Results The patients with N2 down-staging had better prognosis than others. Mediastinal lymph nodes fusion was a significant factor on down-staging outcomes. Meanwhile, gender, age, tumor histology, interval period between chemotherapy and surgery, and chemotherapeutic regimens had no obvious influence on N2 down-staging. Conclusion Patients presenting with single or solitude mediastinal lymph nodes metastasis have better down-staging effect and better prognosis by means of preoperative chemotherapy.

Key words: non-small cell lung cancer neoadjuvant chemotherapy mediastinal lymph nodemetastasis