| 摘要: |
| 目的 探讨胰岛素样生长因子-I(IGF-I)、胰岛素样生长因子-I受体(IGF-IR)在喉鳞癌中的表达及意义.方法 采用逆转录聚合酶链反应(RT-PCR)技术和免疫组织化学技术,检测29例喉鳞癌标本和癌旁正常组织中的IGF-I、IGF-IR的mRNA及其蛋白表达情况.结果 IGF-I、IGF-IR在喉鳞癌中mRNA及其蛋白表达明显高于癌旁正常组织,差别具有显著性意义(P《0.001);肿瘤组织中,在有淋巴结转移组表达量高于无淋巴结转移组(P《0.001).结论 IGF-I、IGF-IR可能在喉鳞癌的发生、发展中起作用;二者可能与颈部淋巴结转移相关. |
| 关键词: 喉鳞肿瘤,胰岛素样生长因子-I,胰岛素样生长因子-I受体,逆转录聚合酶链反应,免疫组织化学 |
| DOI： |
| 修订日期：2007-09-28 |
| 基金项目: |
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| The expression and significance of IGF-I and IGF-IR in laryngeal squamous cell carcinoma |
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| Abstract: |
| Objective To study the expression of IGFI and its receptor(IGF-1R) in laryngeal squamous cell carcinoma(LSCC).Methods mRNA and protein expression of IGF-I and IGF-IR in LSCC tissues and adjacent normal tissues from 29 patients were examined by reverse tra |
| Key words: laryngeal squamous cell carcinoma(LSCC),insulin like growth factors-1(IGF-I),insulin like growth factors-1 receptor(IGF-IR),reverse transcription-polymerase chain reaction(RT-PCR),immunohistochemistry. |
