| 引用本文： |
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侯磊,$2,徐亚伟,张卫国,韩小宁,董果雄.全反式维甲酸对血管平滑肌细胞和p16表达的影响[J].同济大学学报（医学版）,2006,(3):17-20. [点击复制]
- .Effects of All-trans Retinoic Acid on Proliferation of Rat Vascular Smooth Muscle Cells and the Expression of Cyclin- Dependent Kinase Inhibitor p16 Protein[J].同济大学学报（医学版）,2006,(3):17-20. [点击复制]
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| 摘要: |
| 目的探讨全反式维甲酸对大鼠血管平滑肌细胞增生、DNA合成和细胞周期素依赖激酶抑制蛋白p16表达的影响。方法采用血管平滑肌细胞培养,3H-TdR掺入,Western-blotting印迹和图像分析方法。结果全反式维甲酸(2.5μmol/L)明显抑制胎牛血清(20?S)刺激的血管平滑肌细胞增生和DNA合成;全反式维甲酸抑制FBS诱导的血管平滑肌细胞p16蛋白表达下降。结论全反式维甲酸具有抗血管平滑肌细胞增生作用,其机制与促进p16蛋白表达有关。 |
| 关键词: 全反式维甲酸,血管平滑肌细胞,p16蛋白 |
| DOI： |
| 修订日期：2006-02-14 |
| 基金项目: |
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| Effects of All-trans Retinoic Acid on Proliferation of Rat Vascular Smooth Muscle Cells and the Expression of Cyclin- Dependent Kinase Inhibitor p16 Protein |
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| Abstract: |
| Objective To investigate the effects of alltrans retinoic acid(ATRA) on proliferation of rat vascular smooth muscle cells and the expression of Cyclin-Dependent Kinase(CDK) Inhibitor p16 protein.Methods Cell culture of vascular smooth muscle cell,3HTdR in |
| Key words: All-trans retinoic acid,vascular smooth muscle cells,p16 |
