| 摘要: |
| 目的研究染料木黄酮对人HO-8910卵巢癌细胞的抑制效应和诱导凋亡作用,探讨其机制。方法将不同浓度的染料木黄酮作用于人HO-8910卵巢癌细胞,利用MTT法检测其有效作用浓度,分别采用瑞氏染色、TUNEL、流式细胞仪观察和检测HO-8910细胞凋亡情况。结果MTT法测得其IC50值为28.63 mg/L,浓度为8~128 mg/L的染料木黄酮具有诱导人HO-8910卵巢癌细胞凋亡的作用,且随药物作用时间延长凋亡率逐渐增加。结论染料木黄酮具有抗卵巢癌作用,其重要作用机制之一是诱导人HO-8910卵巢癌细胞凋亡。 |
| 关键词: 染料木黄酮,卵巢肿瘤,凋亡,HO-8910细胞系 |
| DOI： |
| 修订日期：2006-01-18 |
| 基金项目: |
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| Genistein Induces Apoptosis in Human HO-8910 Ovarian Cancer Cells |
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| Abstract: |
| Objective To study the mechanisms of genistein inhibiting human ovarian cancer.Methods MTT assay was used to identify the effect of genistein on HO-8910 cells in vitro.HO-8910 cell apoptosis was detected by Wright's staining,TUNEL and flow cytometry.Resul |
| Key words: genistein,ovarian neoplasms,apoptosis,HO8910 cells |
