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张润峰,胡大一,陈运贞,唐克新,马国中,黄宣银.电刺激小脑顶核对心肌梗死大鼠心率变异性的作用[J].同济大学学报(医学版),2006,(2):1-. [点击复制]
- .Effects of Fastigial Nucleus Electro-Stimulation on Heart Rate Variability in Myocardial Infarction Rats[J].同济大学学报(医学版),2006,(2):1-. [点击复制]
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摘要: |
目的观察预先电刺激小脑顶核(fastigial nucleus stimulation,FNS)对心肌梗死(myocardial infarction,MI)大鼠心率变异性(heart rate variability,HRV)的作用。方法成年雄性Wistar大鼠60只,随机分为:(1)MI组,结扎左冠状动脉前降支(left anterior descending artery,LAD);(2)预先电刺激小脑顶核1h再予以左冠状动脉结扎组(FNS+MI组):(3)毁损小脑顶核(fastigial nucleus lesion,FNL)5d后电刺激小脑顶核1h,再行左冠状动脉结扎组(FNL+FNS+MI组)。(4)假手术组(Sham组),开胸术后仅在LAD下穿线但不结扎,电极插入小脑顶核,但不予以刺激。各组又分开胸术后1、7、21d3个时间点,分别采用微机大鼠心率变异性记录分析系统进行心率变异性的频域分析和非线性分析。结果MI组与Sham组比较,频域分析指标-低频(low frequency,LF)、高频(high frequency,HF)、标准化的高频(normalized high frequency,HFnorm)均显著降低(P〈0.05或P〈0,01),标准化的低频(normalized low frequency,LFnorm)与LF/HF比值升高(P〈0.01);非线性分析指标一分形维数(fractal dimension,FD)明显降低(P〈0.05或P〈0.01)。FNS+MI组与MI组比较,MI后各时间点HRV参数HF、LF、HFnorm、FD等明显升高(P〈0.05或P〈0.01),而LFnorm、LF/HF降低(P〈0.01)。FNL+FNS+MI组与MI组比较,HRV各参数无显著性差异(P〉0.05)。结论电刺激小脑顶核可改善心肌梗死大鼠心率变异性。 |
关键词: 小脑核 电刺激 心率变异性 心肌梗死 大鼠 |
DOI: |
修订日期:2005-10-26 |
基金项目:国家自然科学基金资助项目(30571780);四川省科技攻关研究计划项目(04SG022-022);绵阳市科技计划项目(2003S012,2004BS023) |
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Effects of Fastigial Nucleus Electro-Stimulation on Heart Rate Variability in Myocardial Infarction Rats |
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Abstract: |
Objective To investigate the effects of fastigial nucleus electro-stimulation(FNS) in advance on heart rate variability(HRV) in rats with myocardial infarction(MI).Methods Sixty adult male Wistar rats were randomly divided into four groups: group MI was r |
Key words: fastigial nucleus electric stimulation heart rate variability myocardial infarction rat |