| 引用本文： |
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赵江民,李铭,$2.兔心肌梗死过程MRI上心室壁变薄的病理基础研究[J].同济大学学报（医学版）,2005,(3):8-12. [点击复制]
- .A Study on MR Imaging of the Thinning of Left Ventricular Wall during Myocardial Infarction in Rabbits in Correlation with Its Pathology[J].同济大学学报（医学版）,2005,(3):8-12. [点击复制]
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| 摘要: |
| 目的探讨免心肌梗死不同时期在MRI上心室壁变薄的病理基础。方法通过结扎冠状动脉制备免心左室前壁梗死模型，行多次心脏MRI检查，对正常及各缺血时间点梗死心肌标本进行TTC染色、HE染色及透射电镜观察。结果(1)MRI缺血早期缺血室壁即轻度变薄，以收缩期明显；然后逐渐加重，收缩期及舒张期均变薄；至4周瘢痕形成后，其厚度固定不变。(2)TTC染色缺血30min缺血室壁轻度变薄；1h～2周，梗死室壁明显变薄；4周后，梗死区菲薄，纤维瘢痕形成。(3)光镜缺血30min缺血区肌纤维间隙变窄，血管闭塞，肌纤维变细；1h细胞间隙稍有增宽，肌纤维断裂，逐渐加重，肌纤维呈波浪状改变；4周梗死区纤维疤痕形成。(4)电镜缺血30min肌原纤维Ⅰ带增宽，血管闭塞；1h肌纤维远端肌原纤维断裂；4h肌原纤维有溶解。结论缺血后心室壁变薄的原因各期不同，缺血早期是由于心室内张力牵拉使心肌细胞呈舒张状态变细、间隙变窄及血管闭塞所致：急性梗死期，主要因心室内张力牵拉及心肌纤维断裂所致：而梗死后期则由纤维瘢痕收缩引起。 |
| 关键词: 心肌梗死 磁共振成像 左心室壁变薄 病理学 兔 |
| DOI： |
| 修订日期：2004-10-13 |
| 基金项目:上海市科委基金资助项目(034119931) |
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| A Study on MR Imaging of the Thinning of Left Ventricular Wall during Myocardial Infarction in Rabbits in Correlation with Its Pathology |
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| Abstract: |
| Objective To study the pathologic basis of thinning of anterior wall of left ventricle at different stage in myocardial infarction with MR in rabbits.Methods Cardiac cine-MR imaging was performed.The cardiac specimens were stained with TTC,HE and studied |
| Key words: myocardial infarction,magnetic resonance imaging,thinning of wall of left ventricle,pathology,rabbits |
