| 摘要: |
| 目的 研究氧自由基与心肌肥厚的关系。方法 60只大鼠随机分为两组，试验组30只大鼠，腹主动脉结扎，使其狭窄40％；对照组30只大鼠，剖腹、分离腹主动脉，但不结扎。结果 4个月后试验组大鼠心肌重量增加，LPO（过氧化脂质）含量升高，SOD（超氧化物歧化酶）活性下降，与对照组相比差异显著（P＜0．01）；全心重／体重和左心室重／体重与心肌组织LPO含量呈显著正相关（r分别为0．6904和0．6271）与SOD活性呈显著负相关（r分别为－0．6514和－0．6840）。结论 氧自由基可能参与了心肌肥厚的发生和发展。 |
| 关键词: 氧自由基 心肌肥厚 过氧化脂质 超氧化物歧化酶 大鼠 |
| DOI： |
| 修订日期：2001-10-27 |
| 基金项目: |
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| The Relation between Experimental Myocardial Hypertrophy and Oxygen Free Radicals in Rats |
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| Abstract: |
| Objective To explore whether oxygen free radicals are involved in the development of experimental myocardial hypertrophy in rats or not.Methods 60 rats were divided into two groups.In experimental group,30 rats had their abdominal aorta ligated with a 4 |
| Key words: oxygen free radicals,myocardial hypertrophy,lipid peroxide,superoxide dismutase,rats |
